The DOI matches its Crossref record.
Stimulation of Microtubule Aster Formation and Spindle Assembly by the Small GTPase Ran
Abstract
Ran, a small guanosine triphosphatase, is suggested to have additional functions beyond its well-characterized role in nuclear trafficking. Guanosine triphosphate–bound Ran, but not guanosine diphosphate–bound Ran, stimulated polymerization of astral microtubules from centrosomes assembled on Xenopus sperm. Moreover, a Ran allele with a mutation in the effector domain (RanL43E) induced the formation of microtubule asters and spindle assembly, in the absence of sperm nuclei, in a γTuRC (γ-tubulin ring complex)– and XMAP215 ( Xenopus microtubule associated protein)–dependent manner. Therefore, Ran could be a key signaling molecule regulating microtubule polymerization during mitosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
HURP is part of a Ran-dependent complex involved in spindle formation
Koffa, M. D., Casanova, C. M., Santarella, R., Köcher, T., Wilm, M., & Mattaj, I. W. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.056 · Cited by 250
Cai, S., Weaver, L. N., Ems-McClung, S. C., & Walczak, C. E. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-09-0971 · Cited by 189
Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity
Zhang, X., Ems-McClung, S. C., & Walczak, C. E. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-02-0198 · Cited by 123
A picornavirus protein interacts with Ran-GTPase and disrupts nucleocytoplasmic transport
Porter, F. W., Bochkov, Y. A., Albee, A. J., Wiese, C., & Palmenberg, A. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605375103 · Cited by 112
Microtubule assembly during mitosis – from distinct origins to distinct functions?
Meunier, S., & Vernos, I. (2012) · Journal of Cell Science · doi:10.1242/jcs.092429 · Cited by 112
Metadata
- Authors
- Wilde, A., & Zheng, Y.
- Venue
- Science
- Published
- 1999-05-21
- Volume
- 284
- Issue
- 5418
- Pages
- 1359-1362
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966723276
- Cited by
- 395
- References
- 0
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Stimulation of Microtubule Aster Formation and Spindle Assembly by the Small GTPase Ran. https://app.cochat.ai/papers/10.1126/science.284.5418.1359
- The paper
- Wilde, A., & Zheng, Y. (1999). Stimulation of Microtubule Aster Formation and Spindle Assembly by the Small GTPase Ran. Science. https://doi.org/10.1126/science.284.5418.1359
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
