The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
Abstract
Interferons (IFNs) are the most important cytokines in antiviral immune responses. “Natural IFN-producing cells” (IPCs) in human blood express CD4 and major histocompatibility complex class II proteins, but have not been isolated and further characterized because of their rarity, rapid apoptosis, and lack of lineage markers. Purified IPCs are here shown to be the CD4 + CD11c − type 2 dendritic cell precursors (pDC2s), which produce 200 to 1000 times more IFN than other blood cells after microbial challenge. pDC2s are thus an effector cell type of the immune system, critical for antiviral and antitumor immune responses.
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Infection of human epithelial cells with RSV results in significant epithelial membrane barrier disruption, characterized by a decrease in transepithelial electrical resistance and changes in paracellular permeability mediated by a cellular cytoskeletal rearrangement.
“Infection of human epithelial cells with RSV results in significant epithelial membrane barrier disruption, characterized by a decrease in transepithelial electrical resistance and changes in paracellular permeability mediated by a cellular cytoskeletal rearrangement (266).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [266]
Respiratory viruses induce perturbations in the continuity of the epithelial barrier.
“Respiratory viruses also induce perturbations in the continuity of the epithelial barrier.”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [266]
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References 27 · Cited by 2,293
- Authors
- Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., & Liu, Y.-J.
- Affiliations
- Albert Einstein College of Medicine (US)
- DNAX Research Institute, Palo Alto, CA 94304, USA.
- Long Island University (US)
- Rutgers New Jersey Medical School (US)
- Corresponding author
- Siegal, Frederick P.
- Venue
- Science
- Published
- 1999-06-11
- Volume
- 284
- Issue
- 5421
- Pages
- 1835-1837
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2006772331
- Cited by
- 2,293
- References
- 27
- Citations by year
- 2026: 16 · 2025: 33 · 2024: 53 · 2023: 41 · 2022: 47 · 2021: 51 · 2020: 65 · 2019: 73 · 2018: 62 · 2017: 70 · 2016: 55 · 2015: 73 · 2014: 75 · 2013: 92 · 2012: 92
- FWCI
- 34.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- type I interferon, interferon-producing cells, plasmacytoid dendritic cells, antiviral immunity, MHC class II, CD4+ T cells, microbial challenge, antitumor immunity
- MeSH terms
- Cell Separation, Cells, Cultured, Dendritic Cells, Humans, Interferon Type I, Interleukin-3, Leukocytes, Mononuclear, Membrane Glycoproteins, RNA, Messenger, Stem Cells, Organelles, Interferon-alpha, Interferon-beta, Simplexvirus, Cell Lineage, CD40 Ligand
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