Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease
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- NADPH oxidases as electrochemical generators to produce ion fluxes and turgor in fungi, plants and humansAnthony Walter Segal · 2016 · Open Biology
- ATP and guanine nucleotide dependence of neutrophil activation. Evidence for the involvement of two distinct GTP-binding proteins.Diane J. Lu, Sergio Grinstein · 1990 · Journal of Biological Chemistry
- Inhibition of neutrophil NADPH oxidase assembly by a myristoylated pseudosubstrate of protein kinase C.Arthur J. Verhoeven, Jeanette H.W. Leusen, G.C. Kessels, Petra M. Hilarius, Dries B.A. de Bont, Rob M. J. Liskamp · 1993 · Journal of Biological Chemistry
- The relationship between alloimmunization and posttransfusion granulocyte survival: experience in a chronic granulomatous disease cohortK.F. Heim, Thomas A. Fleisher, David F. Stroncek, Steven M. Holland, John I. Gallin, Harry L. Malech, Susan F. Leitman · 2010 · Transfusion
- Chronic granulomatous diseaseAnthony Walter Segal · 1991 · Clinical & Experimental Allergy
- Chronic Granulomatous Disease of Childhood: Clinical, Pathological, Biochemical, Molecular, and Genetic Aspects of the DiseaseRobert L. Baehner · 1990 · Pediatric Pathology
- Identification of the defective NADPH‐oxidase component in Chronic Granulomatous Disease: a study of 57 European familiesColin M. Casimir, Margaret C. Chetty, Marie‐Christine Bohler, R C Garcia, Alain Fischer, C Griscelli, Beryl Johnson, Anthony Walter Segal · 1992 · European Journal of Clinical Investigation
- The p67-phox cytosolic peptide of the respiratory burst oxidase from human neutrophils. Functional aspects.Nobuyuki Okamura, Bernard M. BABIOR, Laura Mayo, Paola Peveri, Roger M. Smith, J T Curnutte · 1990 · Journal of Clinical Investigation
- Oxime-Based Receptors for Mono- and DisaccharidesMonika Mazik, Arno C. Buthe · 2007 · The Journal of Organic Chemistry
- NADPH Oxidase Activity and Cytochromeb558Content of Human Epstein-Barr-Virus-Transformed B Lymphocytes Correlate with Expression of Genes Encoding Components of the Oxidase SystemAntônio Condino‐Neto, Peter E. Newburger · 1998 · Archives of Biochemistry and Biophysics
- Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporineChristophe Combadière, Jamel El Benna, Eric Pédruzzi, J Hakim, Axel Périanin · 1993 · Blood
- Regulation of the Phagocyte Respiratory Burst Oxidase by Protein InteractionsJ. David Lambeth · 2000 · BMB Reports
- Molecular analysis in three cases of X91- variant chronic granulomatous diseaseHanan N. Bu-Ghanim, Anthony Walter Segal, N.H. Keep, Colin M. Casimir · 1995 · Blood
- Use of an Affinity Label to Probe the Function of the NADPH Binding Component of the Respiratory Burst Oxidase of Human NeutrophilsRoger M. Smith, J T Curnutte, Laura Mayo, Bernard M. BABIOR · 1989 · Journal of Biological Chemistry
- Redox signaling at invasive microdomains in cancer cellsBegoña Díaz, Sara A. Courtneidge · 2011 · Free Radical Biology and Medicine
- Neutrophil function screenlng in patients with chronic granulomatous disease by a flow cytometric methodC. Lorrie Epling, D P Stites, Thomas M. McHugh, H. O. Chong, Linda L. Blackwood, D. W. Wara · 1992 · Cytometry
- Influences of lovastatin administration on the respiratory burst of leukocytes and the phosphorylation potential of mitochondria in guinea pigsBecky A. Diebold, Nadhipuram V. Bhagavan, Richard John Guillory · 1994 · Biochimica et Biophysica Acta (BBA) - General Subjects
- A diacylglycerol kinase inhibitor, R 59 022, potentiates superoxide anion production and 46-kDa protein phosphorylation in guinea pig polymorphonuclear leukocytes.Takashi Ohtsuka, Masanori Hiura, K. Yoshida, Nobuyuki Okamura, Shun Ishibashi · 1990 · Journal of Biological Chemistry
- Superoxide-producing cytochrome b. Enzymatic and electron paramagnetic resonance properties of cytochrome b558 purified from neutrophils.Yasuhiro Isogai, Tetsutarō Iizuka, Ryu Makino, Takashi Iyanagi, Y Orii · 1993 · Journal of Biological Chemistry
- The TGF-β/NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and DiseaseMacarena Herranz‐Itúrbide, Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Esther Bertrán, Isabel Fabregat · 2021 · Cells
- Genomic Structure of the Human p47-phox (NCF1) GeneStephen Jacob Chanock, Joachim Roesler, Shixing Zhan, Penelope J. Hopkins, Pauline L. Lee, D. Barrett, Barbara L. Christensen, John T. Curnutte, Agnes Görlach · 2000 · Blood Cells Molecules and Diseases
- Phosphorylation of p40-phox during activation of neutrophil NADPH oxidaseAkimasa Someya, Hiroyuki Nunoi, Takeshi Hasebe, Isao Nagaoka · 1999 · Journal of Leukocyte Biology
- The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous diseaseAnthony Walter Segal · 1989 · Biochemical Society Transactions
- Multiple PU.1 sites cooperate in the regulation ofp40phox transcription during granulocytic differentiation of myeloid cellsSenlin Li, Anthony J. Valente, Mei Qiang, Werner Schlegel, Maria J. Gamez, Robert A. Clark · 2002 · Blood
- Effect of sodium sulfite on mast cell degranulation and oxidant stressChristopher R. Collaco, Daniel J. Hochman, Randall M. Goldblum, Edward G. Brooks · 2006 · Annals of Allergy Asthma & Immunology
- Remodeling of the plasma membrane after stimulation of neutrophils with f-Met-Leu-Phe and dihydrocytochalasin B: identification of membrane subdomains containing NADPH oxidase activityGoutam Mukherjee, Mark T. Quinn, John Gunnar Linner, Algirdas J. Jesaitis · 1994 · Journal of Leukocyte Biology
- Activation factors of neutrophil NADPH oxidase complexShigenobu Umeki · 1994 · Life Sciences
- Cytosolic factors in bovine neutrophil oxidase activation. Partial purification and demonstration of translocation to a membrane fractionJacques Doussière, Marie‐Claire Dagher, Pierre V. Vignais · 1990 · Biochemistry
- Four different NCF2 mutations in six families from Turkey and an overview of NCF2 gene mutationsMustafa Yavuz Köker, Özden Sanal, Karin van Leeuwen, Martin de Boer, Ayşe Metìn, Türkan Patıroğlu, Tuba Turul Özgür, İlhan Tezcan, Dirk Roos · 2009 · European Journal of Clinical Investigation
- Six different CYBA mutations including three novel mutations in ten families from Turkey, resulting in autosomal recessive chronic granulomatous diseaseMustafa Yavuz Köker, Karin van Leeuwen, Martin de Boer, Fatih Çelmeli, Ayşe Metìn, Tuba Turul Özgür, İlhan Tezcan, Özden Sanal, Dirk Roos · 2009 · European Journal of Clinical Investigation
- Escherichia coli-host macrophage interactions in the pathogenesis of inflammatory bowel disease.Ahmed Tawfik, Paul K. Flanagan, Barry James Campbell · 2014 · PubMed Central
- Cytosolic oxidase factors in the NADPH‐dependent oxidase of human neutrophilsWilliam Michael Nauseef · 1993 · European Journal Of Haematology
- Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infectionsIsrael Cotzomi-Ortega, Emily E. Rosowski, Xin Wang, Yuriko I. Sánchez-Zamora, Jeimy M Lopez-Torres, Gamaliel Sanchez-Orellana, Rachel Han, Gabriela Vasquez-Martinez, Gabriel Mayoral Andrade, Gregory A. Ballash et al. · 2024 · Mucosal Immunology
- Purification and characterization of an oxidase activating factor of 63-kilodaltons from bovine neutrophilsMarie‐Claire Dagher, Pierre V. Vignais · 1991 · Biochemistry
- Chronic granulomatous disease and glutathione peroxidase deficiency, revisitedPeter E. Newburger, S E Malawista, Mary C. Dinauer, Terri Gelbart, RC Woodman, Sunil Chada, Qichang Shen, G Van Blaricom, PG Quie, J T Curnutte · 1994 · Blood
- Activation of NADPH oxidase in human neutrophils permeabilized with Staphylococcus aureus alpha-toxin. A lower Km when the enzyme is activated in situ.Sue A. Bauldry, V N Nasrallah, David Bass · 1992 · Journal of Biological Chemistry
- A 63-kilodalton cytosolic polypeptide involved in superoxide generation in porcine neutrophils. Purification and characterization.Toshitake Tanaka, Shinobu Imajoh‐Ohmi, Shiro Kanegasaki, Y Takagi, Ryu Makino, Yuzuru Ishimura · 1990 · Journal of Biological Chemistry
- Cell-Free NADPH Oxidase Activation Assays: A Triumph of ReductionismEdgar Pick · 2019 · Methods in molecular biology
- Pre-B Cell Colony-Enhancing Factor (PBEF/Nampt/Visfatin) Primes Neutrophils for Augmented Respiratory Burst Activity through Partial Assembly of the NADPH OxidaseZeenat Malam, Jean C Parodo, Faiza Waheed, Katalin Szászi, András Kapùs, John C. Marshall · 2011 · The Journal of Immunology
- Delineation of the phagocyte NADPH oxidase through studies of chronic granulomatous diseases of childhoodJohn I. Gallin, Thomas L. Leto, Daniel Rotrosen, Cheung H. Kwong, Harry L. Malech · 1992 · Current Opinion in Immunology
- Intracellular production of reactive oxygen species in human neutrophils following activation by the soluble stimuli FMLP, dioctanoylglycerol and ionomycinPer Follin, Agneta Johansson, Cláes Dahlgren · 1991 · Cell Biochemistry and Function
- Two cytosolic components of the neutrophil NADPH oxidase, P47-PHOX and P67-PHOX, are not flavoproteinsTsukasa Chiba, Mizuho Kaneda, Hirotada G. Fujii, Robert A. Clark, William Michael Nauseef, Katsuko Kakinuma · 1990 · Biochemical and Biophysical Research Communications
- Transcriptional Regulation of the p67 GeneSen-Lin Li, Anthony J. Valente, Long Wang, Maria J. Gamez, Robert A. Clark · 2001 · Journal of Biological Chemistry
- Identification of a thermolabile component of the human neutrophil NADPH oxidase. A model for chronic granulomatous disease caused by deficiency of the p67-phox cytosolic component.Richard W. Erickson, Stephen E. Malawista, M.C. Garrett, G Van Blaricom, Thomas L. Leto, J T Curnutte · 1992 · Journal of Clinical Investigation
- Characterization of peptide diffusion into electropermeabilized neutrophilsFrank R. DeLeo, Mark A. Jutila, Mark T. Quinn · 1996 · Journal of Immunological Methods
- Immunochemical and electrophoretic analyses of phosphorylated native and recombinant neutrophil oxidase component p47-phoxWM Nauseef, Bryan D. Volpp, Robert A. Clark · 1990 · Blood
- Nucleotide binding properties of cytosolic components required for expression of activity of the superoxide generating NADPH oxidaseDoron Sha'ag, Edgar Pick · 1990 · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
- Chapter 4 Signal Transduction by GTP Binding Proteins during Leukocyte Activation: Phagocytic CellsGary Bokoch · 1990 · Current topics in membranes and transport
- Mice lacking NOX2 are hyperphagic and store fat preferentially in the liverSheila R. Costford, Jason Castro-Alves, Kenny L. Chan, Liane Jennifer Bailey, Minna Woo, Denise D. Belsham, John Hunter Brumell, Amira Klip · 2014 · American Journal of Physiology-Endocrinology and Metabolism
- Successful Interferon-γ Therapy in a Chronic Granulomatous Disease (CGD) Patient Suffering from Staphylococcus aureus Hepatic Abscess and Invasive Candida albicans InfectionBo‐Eric Malmvall, Per Follin · 1993 · Scandinavian Journal of Infectious Diseases
- Evidence that Activation of the Respiratory Burst Oxidase in a Cell-Free System from Human Neutrophils is Accomplished in Part Through an Alteration of the Oxidase-Related 67-kDa Cytosolic ProteinSadaki Fujimoto, Roger M. Smith, J T Curnutte, Bernard M. BABIOR · 1989 · Journal of Biological Chemistry
- AG dinucleotide insertion in a patient with chronic granulomatous disease lacking cytosolic 67-kD proteinHiroyuki Nunoi, M Iwata, S Tatsuzawa, Yoshihito Onoe, S Shimizu, Shiro Kanegasaki, Ichiro Matsuda · 1995 · Blood
- Altered expression of neutrophil peripheral benzodiazepine receptor in X-linked chronic granulomatous diseaseFlora Zavala, Florence Veber, Béatrice Descamps‐Latscha · 1990 · Blood
- NADH oxidase activity of rat liver plasma membrane activated by guanine nucleotidesD. James Morré, M Davidson, Christoph C. Geilen, James Lawrence, G Flesher, Ruth A. Crowe, F.L. Crane · 1993 · Biochemical Journal
- NADPH:O2 oxidoreductase of human eosinophils in the cell‐free systemBen G.J.M. Bolscher, Leo Koenderman, Anton T. J. Tool, Petra M. Hilarius, Dirk Roos · 1990 · FEBS Letters
- The NADPH oxidase of phagocytic cells is an electron pump that alkalinises the phagocytic vacuoleAnthony Walter Segal · 1995 · PROTOPLASMA
- The requirement of p47 phosphorylation for activation of NADPH oxidase by opsonized zymosan in human neutrophilsRachel Lévy, Raya Dana, Thomas L. Leto, Harry L. Malech · 1994 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Intersecting Stories of the Phagocyte NADPH Oxidase and Chronic Granulomatous DiseaseWilliam Michael Nauseef, Robert A. Clark · 2019 · Methods in molecular biology
- NOX1 NADPH oxidase regulation by the NOXA1 SH3 domainAnthony J. Valente, Amina El Jamali, Terry Kay Epperson, Maria J. Gamez, Doran W. Pearson, Robert A. Clark · 2007 · Free Radical Biology and Medicine
- Retroviral expression of recombinant p47phox protein by Epstein-Barr virus-transformed B lymphocytes from a patient with autosomal chronic granulomatous diseaseCS Cobbs, Harry L. Malech, TL Leto, S M Freeman, R. Michael Blaese, John I. Gallin, KJ Lomax · 1992 · Blood
- Are Plants Stacked Neutrophiles? Comparison of Pathogen-Induced Oxidative Burst in Plants and MammalsSabine Lüthje, Michael Böttger, Olaf Döring · 2000 · Progress in botany
- Reconstitution of defective respiratory burst activity with partially purified human neutrophil cytochrome B in two genetic forms of chronic granulomatous disease: possible role of Rap1AMark T. Quinn, J T Curnutte, CA Parkos, ML Mullen, PJ Scott, RW Erickson, Algirdas J. Jesaitis · 1992 · Blood
- Low NADPH oxidase activity in Epstein-Barr-virus-immortalized B-lymphocytes is due to a post-transcriptional block in expression of cytochrome b558Margaret C. Chetty, Adrian James Thrasher, Arie Abo, Colin M. Casimir · 1995 · Biochemical Journal
- Peroxiredoxin-6 and NADPH Oxidase ActivityDaniel R. Ambruso · 2013 · Methods in enzymology on CD-ROM/Methods in enzymology
- Prolactin-induced activation of phagocyte NADPH oxidase in the teleost fish gilthead seabream involves the phosphorylation of p47phox by protein kinase CVíctor H. Olavarría, Jaime E. Figueroa, Víctoriano Mulero · 2011 · Developmental & Comparative Immunology
- Regulation of Calreticulin Expression during Induction of Differentiation in Human Myeloid CellsRobert A. Clark, Senlin Li, Doran W. Pearson, Kevin G. Leidal, Joshua R. Clark, Gerene M. Denning, Robert Lee Reddick, Karl Heinz Krause, Anthony J. Valente · 2002 · Journal of Biological Chemistry
- Nanobiosensor Design Utilizing a PeriplasmicE. coliReceptor Protein Immobilized within Au/Polycarbonate NanoporesAbhinav Tripathi, Jianbin Wang, Linda A. Luck, Ian Ivar Suni · 2006 · Analytical Chemistry
- Superoxide generation of phagocytes and nonphagocytic cellsBeate Meier · 2001 · PROTOPLASMA
- Human neutrophil cytosolic activation factor of the NADPH oxidase. Characterization of activation kinetics.Shigenobu Umeki · 1990 · Journal of Biological Chemistry
- EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signallingRandzavola, Lyra O, Mortimer, Paige M, Garside, Emma, Dufficy, Elizabeth R, Schejtman, Andrea, Roumelioti, Georgia, Yu, Lu, Pardo, Mercedes, Spirohn, Kerstin, Tolley, Charlotte et al. · 2022 · eLife
- [48] Purification of human neutrophil NADPH oxidase cytochrome b-558 and association with Rap 1AMark T. Quinn, Charles A. Parkos, Algirdas J. Jesaitis · 1995 · Methods in enzymology on CD-ROM/Methods in enzymology
- Mechanisms for the activation/electron transfer of neutrophil NADPH-oxidase complex and molecular pathology of chronic granulomatous diseaseShigenobu Umeki · 1994 · Annals of Hematology
- Translocation of guinea pig p40-phox during activation of NADPH oxidaseAkimasa Someya, Isao Nagaoka, Hiroyuki Nunoi, Tatsuhisa Yamashita · 1996 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Thermodynamics of α-Cyclodextrin−p-Nitrophenyl Glycoside Complexes. A Simple System To Understand the Energetics of Carbohydrate Interactions in WaterElena Junquera, José L. Laynez, Margarita Menéndez, Sunil Kumar Sharma, Soledad Penadés · 1996 · The Journal of Organic Chemistry
- Phosphatase activity regulates superoxide anion generation and intracellular signaling in human neutrophilsJames C. Gay, Khadir Raddassi, A P Truett, JOHN J. MURRAY · 1997 · Biochimica et Biophysica Acta (BBA) - General Subjects
- Production of myeloid cell cytosols functionally and immunochemically deficient in the 47 kDa or 67 kDa NADPH oxidase cytosolic factorsRachel Lévy, Harry L. Malech, Daniel Rotrosen · 1990 · Biochemical and Biophysical Research Communications
- NADPH Oxidase 3: Beyond the Inner EarMarc Herb · 2024 · Antioxidants
- Variants of the 5′-untranslated region of human NCF2: Expression and translational efficiencyKatherine A Gauss, Peggy L Bunger, Matthew A. Crawford, Breanne E. McDermott, Robin Swearingen, Laura K. Nelson-Overton, Daniel W. Siemsen, Scott D. Kobayashi, Frank R. DeLeo, Mark T. Quinn · 2005 · Gene
- The merits of in vitro versus in vivo modeling in investigation of the immune systemChristopher C. Silliman, Michael Wang · 2005 · Environmental Toxicology and Pharmacology
- Reconstitution of the partially purified membrane component of the superoxide‐generating NADPH oxidase of pig neutrophils with phospholipidMasahiko Nozaki, Koichiro Takeshige, Hideki Sumimoto, Shigeki Minakami · 1990 · European Journal of Biochemistry
- Staphylococci surviving intracellularly in phagocytes from patients suffering from chronic granulomatous disease are killed in vitro by antibiotics encapsulated in liposomes.Joachim Roesler, Stefan Hockertz, Birgit Vogt, M L Lohmann-Matthes · 1991 · Journal of Clinical Investigation
- Reactive Oxygen and Reactive Nitrogen Metabolites as Effector Molecules against Infectious PathogensChristian Bogdan · 2014 · ASM Press eBooks
- Pollen NAD(P)H Oxidases and Their Contribution to Allergic InflammationNilesh G. Dharajiya, Attila Bácsi, Istvan R. Boldogh, Sanjiv Sur · 2007 · Immunology and Allergy Clinics of North America
- Monoclonal antibody 7D5 recognizes the R147 epitope on the gp91phox, phagocyte flavocytochrome b558 large subunitChikage Kawai, 明 山内, Futoshi Kuribayashi · 2018 · Microbiology and Immunology
- Tryptophan Phosphorescence Studies of the d -Galactose/ d -Glucose-Binding Protein from Escherichia coli Provide a Molecular Portrait with Structural and Dynamics Features of the ProteinSabato D’Auria, Antonio Varriale, Margherita Gonnelli, Michele Saviano, Maria Staiano, Mosé Rossi, Giovanni Battista STRAMBINI · 2007 · Journal of Proteome Research
- Chronic granulomatous diseaseReinhard A Seger, F. Berthet, J. P. Hossie · 1992 · Pediatric Allergy and Immunology
- Granulocytic PhagocytesWilliam Michael Nauseef, Robert A. Clark · 2010 · Elsevier eBooks
- Cerebral aspergilloma in a child with autosomal recessive chronic granulomatous disease.Andrew F. Dean, Ivan Janota, Adrian James Thrasher, I Robertson, Giorgina Mieli‐Vergani · 1993 · Archives of Disease in Childhood
- Enhancement of Allergen-induced Airway Inflammation by NOX2 DeficiencyHee Yeon Won, Eun Jung Jang, Hyun Jung Min, Eun Sook Hwang · 2011 · Immune Network
- Cytosolic components involved in porcine neutrophil oxidase activation. Purification of a 47-kilodalton protein and reconstitution of the activation system.Toshitake Tanaka, Ryu Makino, Yuzuru Ishimura · 1992 · Journal of Biological Chemistry
- NADPH: nitroblue tetrazolium reductase found in plasma membrane of human neutrophilYukio Nisimoto, Hidetsugu Otsuka-Murakami · 1990 · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
- Comparison of the Oxidative Burst Signaling Pathways of Plants and Human NeutrophilsPhilip Stewart Low, Shannon C. Dwyer · 1994 · Current plant science and biotechnology in agriculture
- Diagnostic Testing for Chronic Granulomatous DiseaseDouglas Byron Kuhns · 2019 · Methods in molecular biology
- A puromycin-dependent activity-based sensing probe for histochemical staining of hydrogen peroxide in cells and animal tissuesKaede Hoshi, Marco S. Messina, Jun Ohata, Clive Yik‐Sham Chung, Christopher J. Chang · 2022 · Nature Protocols
- Family Clusters of Variant X-linked Chronic Granulomatous DiseaseJeffrey M. Bender, Thomas H. Rand, Krow Ampofo, Andrew T. Pavia, Michelle Elena Schober, Anne E. Tebo, Brian M. Pasi, Nancy Hogan Augustine, Robert J. Pryor, Carl T. Wittwer et al. · 2009 · The Pediatric Infectious Disease Journal
- The NADPH Oxidase: Lessons from Chronic Granulomatous Disease NeutrophilsArthur J. Verhoeven · 1997 · Annals of the New York Academy of Sciences
- Characterization of Surface Structure and p47phox SH3 Domain-Mediated Conformational Changes for Human Neutrophil Flavocytochrome bRoss M. Taylor, Connie I. Lord, Marcia H. Riesselman, Jeannie M. Gripentrog, Thomas L. Leto, Linda C. McPhail, Yevgeny Berdichevsky, Edgar Pick, Algirdas J. Jesaitis · 2007 · Biochemistry
- Host Defense Activity in Various HostsShigenobu Umeki, Rinzō Soejima · 1992 · CHEST Journal
- Interferon-γ and chronic granulomatous diseaseMary C. Dinauer, R. Alan B. Ezekowitz · 1991 · Current Opinion in Immunology
- Investigations on apocynin, a potent NADPH oxidase inhibitorEdwin van den Worm · 2001 · Utrecht University Repository (Utrecht University)