The DOI matches its Crossref record.
The Scientific Challenge of Hepatitis C
Abstract
The hepatitis C virus (HCV) infects some 170 million people worldwide--more than four times as many as HIV--and is causing rising rates of liver disease. Like HIV, it is a wily foe for researchers developing drugs and vaccines, because HCV also mutates rapidly, creating a swarm of different viruses in each infected person that can thwart antibodies easily. But progress is beginning to be made: Although to date no one has been able to grow HCV reliably in a laboratory culture of cells, on page 110, researchers describe a new system for culturing HCV9s RNA. And a study on page 107 offers one possible explanation for why some HCV strains are more resistant to interferon, the standard treatment for HCV, than others.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Binding of the Hepatitis C Virus Envelope Protein E2 to CD81 Inhibits Natural Killer Cell Functions
Tseng, C.-T. K., & Klimpel, G. R. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011145 · Cited by 447
Hepatitis C Virus Persistence after Spontaneous or Treatment-Induced Resolution of Hepatitis C
Pham, T. N. Q., MacParland, S. A., Mulrooney, P. M., Cooksley, H., Naoumov, N. V., & Michalak, T. I. (2004) · Journal of Virology · doi:10.1128/jvi.78.11.5867-5874.2004 · Cited by 324
Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor
Arasappan, A., Bennett, F., Bogen, S. L., Venkatraman, S., Blackman, M., Chen, K. X., Hendrata, S., Huang, Y., Huelgas, R. M., Nair, L., et al. (2010) · ACS Medicinal Chemistry Letters · doi:10.1021/ml9000276 · Cited by 102
Metadata
- Authors
- Cohen, J.
- Venue
- Science
- Published
- 1999-07-02
- Volume
- 285
- Issue
- 5424
- Pages
- 26-30
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065306302
- Cited by
- 350
- References
- 0
- FWCI
- 13.52
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Scientific Challenge of Hepatitis C. https://app.cochat.ai/papers/10.1126/science.285.5424.26
- The paper
- Cohen, J. (1999). The Scientific Challenge of Hepatitis C. Science. https://doi.org/10.1126/science.285.5424.26
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
