The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Abstract
Endotoxin, a constituent of Gram-negative bacteria, stimulates macrophages to release large quantities of tumor necrosis factor (TNF) and interleukin-1 (IL-1), which can precipitate tissue injury and lethal shock (endotoxemia). Antagonists of TNF and IL-1 have shown limited efficacy in clinical trials, possibly because these cytokines are early mediators in pathogenesis. Here a potential late mediator of lethality is identified and characterized in a mouse model. High mobility group–1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1. Mice showed increased serum levels of HMG-1 from 8 to 32 hours after endotoxin exposure. Delayed administration of antibodies to HMG-1 attenuated endotoxin lethality in mice, and administration of HMG-1 itself was lethal. Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Self-citationAnti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448
Self-citationDetection of circulating tumor necrosis factor after endotoxin administration
Michie, H. R., Manogue, K. R., Spriggs, D. R., Revhaug, A., O'Dwyer, S., Dinarello, C. A., Cerami, A., Wolff, S. M., & Wilmore, D. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806093182301 · Cited by 1,677
Self-citationThe interleukin‐1 family: 10 years of discovery 1
Dinarello, C. A. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.15.8001745 · Cited by 783
Cited by
Items 101–108 of 108
Zhong, X., Xie, L., Yang, X., Liang, F., Yang, Y., Tong, J., Zhong, Y., Zhao, K., Tang, Y., & Yuan, C. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00181-3 · Cited by 42
Hui, L., Yao, Y., Wang, S., Yu, Y., Dong, N., Li, H., & Sheng, Z. (2009) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/ta.0b013e318164d05f · Cited by 42
Rouillard, M. E., Hu, J., Sutter, P. A., Kim, H. W., Huang, J. K., & Crocker, S. J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.833186 · Cited by 35
Nakano, T., Irie, K., Hayakawa, K., Sano, K., Nakamura, Y., Tanaka, M., Yamashita, Y., Satho, T., Fujioka, M., Muroi, C., et al. (2015) · Brain Research · doi:10.1016/j.brainres.2015.07.027 · Cited by 32
Rao, Z., Zhang, N., Xu, N., Pan, Y., Xiao, M., Wu, J., Zhou, H., Yang, S., & Chen, Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01308 · Cited by 27
Bacterial stimulation of toll-like receptor 4 drives macrophages to hemophagocytose
McDonald, E. M., Pilonieta, M. C., Nick, H. J., & Detweiler, C. S. (2016) · Infection and Immunity · doi:10.1128/iai.01149-15 · Cited by 18
ZHANG, X., LUAN, Z., LIANG, Y., LIU, Y., & MA, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3251 · Cited by 8
Wang, J.-S., Sheu, W. H.-H., Lee, W.-J., Lee, I.-T., Lin, S.-Y., Lee, W.-L., Liang, K.-W., & Lin, S.-J. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.04.032 · Cited by 5
Metadata
- Authors
- Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L., Manogue, K. R., Faist, E., Abraham, E., Andersson, J., Andersson, U., Molina, P. E., Abumrad, N. N., Sama, A., & Tracey, K. J.
- Venue
- Science
- Published
- 1999-07-09
- Volume
- 285
- Issue
- 5425
- Pages
- 248-251
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2164714222
- Cited by
- 3,385
- References
- 4
- FWCI
- 26.03
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
