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Different Trajectories of Parallel Evolution During Viral Adaptation
Abstract
The molecular basis of adaptation is a major focus of evolutionary biology, yet the dynamic process of adaptation has been explored only piecemeal. Experimental evolution of two bacteriophage lines under strong selection led to over a dozen nucleotide changes genomewide in each replicate. At least 96 percent of the amino acid substitutions appeared to be adaptive, and half the changes in one line also occurred in the other. However, the order of these changes differed between replicates, and parallel substitutions did not reflect the changes with the largest beneficial effects or indicate a common trajectory of adaptation.
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Cites
Fitness of RNA virus decreased by Muller’s ratchet
Chao, L. (1990) · Nature · doi:10.1038/348454a0 · Cited by 488
Cited by
Evolution Experiments with Microorganisms: The Dynamics and Genetic Bases of Adaptation
Elena, S. F., & Lenski, R. E. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1088 · Cited by 1,386
Evolution, the Extended Synthesis
(2010) · The MIT Press eBooks · doi:10.7551/mitpress/9780262513678.001.0001 · Cited by 964
Evolutionary paths to antibiotic resistance under dynamically sustained drug selection
Toprak, E., Veres, A., Michel, J.-B., Chait, R., Hartl, D. L., & Kishony, R. (2012) · Nature Genetics · doi:10.1038/ng.1034 · Cited by 764
The genetic causes of convergent evolution
Stern, D. L. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3483 · Cited by 818
Kawecki, T. J., Lenski, R. E., Ebert, D., Hollis, B., Olivieri, I., & Whitlock, M. C. (2012) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2012.06.001 · Cited by 807
Metadata
- Authors
- Wichman, H. A., Badgett, M. R., Scott, L. A., Boulianne, C. M., & Bull, J. J.
- Venue
- Science
- Published
- 1999-07-16
- Volume
- 285
- Issue
- 5426
- Pages
- 422-424
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2090437685
- Cited by
- 383
- References
- 1
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wichman, H. A., Badgett, M. R., Scott, L. A., Boulianne, C. M., & Bull, J. J. (1999). Different Trajectories of Parallel Evolution During Viral Adaptation. Science. https://doi.org/10.1126/science.285.5426.422
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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