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Cited by 383Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

An Adhesin of the Yeast Pathogen Candida glabrata Mediating Adherence to Human Epithelial Cells

Cormack, Brendan P., Ghori, Nafisa, Falkow, Stanley·1999·Science
DOI 10.1126/science.285.5427.578
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Abstract

Candida glabrata is an important fungal pathogen of humans that is responsible for about 15 percent of mucosal and systemic candidiasis. Candida glabrata adhered avidly to human epithelial cells in culture. By means of a genetic approach and a strategy allowing parallel screening of mutants, it was possible to clone a lectin from a Candida species. Deletion of this adhesin reduced adherence of C. glabrata to human epithelial cells by 95 percent. The adhesin, encoded by the EPA1 gene, is likely a glucan-cross-linked cell-wall protein and binds to host-cell carbohydrate, specifically recognizing asialo-lactosyl-containing carbohydrates.

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  • Epa1 is a calcium-dependent lectin that aids adhesion to epithelial cells and macrophages.

    “The founding member of the Epa adhesin family, Epa1, is a calcium-dependent lectin, and aids adhesion to epithelial cells [32] and macrophages [33].”

    From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [32]

  • In vitro adherence of C. glabrata to epithelial cells is primarily mediated by the Epa1 adhesin.

    “Although the in vitro adherence of C. glabrata to epithelial cells is primarily mediated by the Epa1 adhesin [32], Epa6 and Epa7 have been shown to be pivotal to adherence under specific environmental conditions [30,36].”

    From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [32]

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References 33 · Cited by 383

Authors
Cormack, B. P., Ghori, N., & Falkow, S.
Affiliations
Stanford Medicine (US)
Corresponding author
Cormack, Brendan P.
ORCID
Cormack, Brendan P.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1999-07-23
Volume
285
Issue
5427
Pages
578-582
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.285.5427.578
OpenAlex
W2075016274
Cited by
383
References
33
Citations by year
2026: 7 · 2025: 8 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 12 · 2019: 8 · 2018: 19 · 2017: 3 · 2016: 14 · 2015: 24 · 2014: 25 · 2013: 16 · 2012: 18
FWCI
12.84
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
Candida glabrata, adhesins, fungal adhesion, epithelial cells, lectins, cell wall proteins, candidiasis, host-pathogen interaction
MeSH terms
Amino Acid Sequence, Animals, Calcium, Candida, Candidiasis, Vulvovaginal, Carbohydrates, Cell Adhesion, Cloning, Molecular, Epithelial Cells, Female, Fungal Proteins, Genes, Fungal, Humans, Ligands, Mice, Inbred DBA, Molecular Sequence Data, Mutation, Plasmids, Transformation, Genetic, Tumor Cells, Cultured, Virulence, Polymerase Chain Reaction, Mutagenesis, Insertional, Lectins, Mice

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