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Epigenetic Inheritance of Active Chromatin After Removal of the Main Transactivator
Abstract
The Drosophila Polycomb and trithorax group proteins act through chromosomal elements such as Fab-7 to maintain repressed or active gene expression, respectively. A Fab-7 element is switched from a silenced to a mitotically heritable active state by an embryonic pulse of transcription. Here, histone H4 hyperacetylation was found to be associated with Fab-7 after activation, suggesting that H4 hyperacetylation may be a heritable epigenetic tag of the activated element. Activated Fab-7 enables transcription of a gene even after withdrawal of the primary transcription factor. This feature may allow epigenetic maintenance of active states of developmental genes after decay of their early embryonic regulators.
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Citations
Cites
The Drosophila Fab-7 Chromosomal Element Conveys Epigenetic Inheritance during Mitosis and Meiosis
Cavalli, G., & Paro, R. (1998) · Cell · doi:10.1016/s0092-8674(00)81181-2 · Cited by 367
Self-citation
Cited by
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Czermin, B., Melfi, R., McCabe, D., Seitz, V., Imhof, A., & Pirrotta, V. (2002) · Cell · doi:10.1016/s0092-8674(02)00975-3 · Cited by 1,533
Parental olfactory experience influences behavior and neural structure in subsequent generations
Dias, B. G., & Ressler, K. J. (2014) · Nature Neuroscience · doi:10.1038/nn.3594 · Cited by 1,338
Polycomb silencing mechanisms and the management of genomic programmes
Schwartz, Y. B., & Pirrotta, V. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1981 · Cited by 868
Metadata
- Authors
- Cavalli, G., & Paro, R.
- Venue
- Science
- Published
- 1999-10-29
- Volume
- 286
- Issue
- 5441
- Pages
- 955-958
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000160108
- Cited by
- 239
- References
- 1
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- closed
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