The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Identification of a Conserved Receptor-Binding Site on the Fiber Proteins of CAR-Recognizing Adenoviridae
Abstract
The human adenovirus serotype 5 (Ad5) is used widely for applications in human gene therapy. Cellular attachment of Ad5 is mediated by binding of the carboxyl-terminal knob of its fiber coat protein to the Coxsackie adenovirus receptor (CAR) protein. However, Ad5 binding to CAR hampers the development of adenovirus vectors capable of specifically targeting (diseased) tissues or organs. Through sequence analysis and mutagenesis, a conserved receptor-binding region was identified on the side of three divergent CAR-binding knobs. The feasibility of simultaneous CAR ablation and redirection of an adenovirus to a new receptor is demonstrated.
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Cites
Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
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Self-citationStructural Analysis of the Mechanism of Adenovirus Binding to Its Human Cellular Receptor, CAR
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Cited by
Kirn, D., Martuza, R. L., & Zwiebel, J. (2001) · Nature Medicine · doi:10.1038/89901 · Cited by 502
Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor HveA
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Adenovirus Type 37 Uses Sialic Acid as a Cellular Receptor
Arnberg, N., Edlund, K., Kidd, A. H., & Wadell, G. (2000) · Journal of Virology · doi:10.1128/jvi.74.1.42-48.2000 · Cited by 316
CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors
Alemany, R., & Curiel, D. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301515 · Cited by 294
Metadata
- Authors
- Roelvink, P. W., Lee, G. M., Einfeld, D. A., Kovesdi, I., & Wickham, T. J.
- Venue
- Science
- Published
- 1999-11-19
- Volume
- 286
- Issue
- 5444
- Pages
- 1568-1571
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065424348
- Cited by
- 406
- References
- 16
- FWCI
- 21.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Roelvink, P. W., Lee, G. M., Einfeld, D. A., Kovesdi, I., & Wickham, T. J. (1999). Identification of a Conserved Receptor-Binding Site on the Fiber Proteins of CAR-Recognizing Adenoviridae. Science. https://doi.org/10.1126/science.286.5444.1568
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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