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Functional Human Corneal Equivalents Constructed from Cell Lines
Abstract
Human corneal equivalents comprising the three main layers of the cornea (epithelium, stroma, and endothelium) were constructed. Each cellular layer was fabricated from immortalized human corneal cells that were screened for use on the basis of morphological, biochemical, and electrophysiological similarity to their natural counterparts. The resulting corneal equivalents mimicked human corneas in key physical and physiological functions, including morphology, biochemical marker expression, transparency, ion and fluid transport, and gene expression. Morphological and functional equivalents to human corneas that can be produced in vitro have immediate applications in toxicity and drug efficacy testing, and form the basis for future development of implantable tissues.
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Cited by
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Zimmermann, K. C., Bonzon, C., & Green, D. R. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00159-0 · Cited by 833
A Review of Three-Dimensional In Vitro Tissue Models for Drug Discovery and Transport Studies
Elliott, N. T., & Yuan, F. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22257 · Cited by 449
Solomon, A., Ellies, P., Anderson, D. F., Touhami, A., Grueterich, M., Espana, E. M., Ti, S.-E., Goto, E., Feuer, W. J., & Tseng, S. C. G. (2002) · Ophthalmology · doi:10.1016/s0161-6420(02)00960-0 · Cited by 349
Mucin Gene Expression in Immortalized Human Corneal–Limbal and Conjunctival Epithelial Cell Lines
Gipson, I. K., Spurr-Michaud, S., Argu¨eso, P., Tisdale, A., Ng, T. F., & Russo, C. L. (2003) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.02-0851 · Cited by 345
Multipotent Stem Cells in Human Corneal Stroma
Du, Y., Funderburgh, M. L., Mann, M. M., SundarRaj, N., & Funderburgh, J. L. (2005) · STEM CELLS · doi:10.1634/stemcells.2004-0256 · Cited by 335
Metadata
- Authors
- Griffith, M., Osborne, R., Munger, R., Xiong, X., Doillon, C. J., Laycock, N. L. C., Hakim, M., Song, Y., & Watsky, M. A.
- Venue
- Science
- Published
- 1999-12-10
- Volume
- 286
- Issue
- 5447
- Pages
- 2169-2172
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981013532
- Cited by
- 464
- References
- 0
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Griffith, M., Osborne, R., Munger, R., Xiong, X., Doillon, C. J., Laycock, N. L. C., Hakim, M., Song, Y., & Watsky, M. A. (1999). Functional Human Corneal Equivalents Constructed from Cell Lines. Science. https://doi.org/10.1126/science.286.5447.2169
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
