The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44 MAPK -Dependent Phosphorylation
Abstract
The mitogen-activated protein (MAP) kinase cascade is inactivated at the level of MAP kinase by members of the MAP kinase phosphatase (MKP) family, including MKP-1. MKP-1 was a labile protein in CCL39 hamster fibroblasts; its degradation was attenuated by inhibitors of the ubiquitin-directed proteasome complex. MKP-1 was a target in vivo and in vitro for p42 MAPK or p44 MAPK , which phosphorylates MKP-1 on two carboxyl-terminal serine residues, Serine 359 and Serine 364. This phosphorylation did not modify MKP-1's intrinsic ability to dephosphorylate p44 MAPK but led to stabilization of the protein. These results illustrate the importance of regulated protein degradation in the control of mitogenic signaling.
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Cites
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Cited by
Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival
Junttila, M. R., Li, S., & Westermarck, J. (2008) · The FASEB Journal · doi:10.1096/fj.06-7859rev · Cited by 826
Dual-specificity phosphatases: critical regulators with diverse cellular targets
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Bhalla, U. S., Ram, P. T., & Iyengar, R. (2002) · Science · doi:10.1126/science.1068873 · Cited by 631
Dual‐specificity MAP kinase phosphatases (MKPs): Shaping the outcome of MAP kinase signalling
Caunt, C. J., & Keyse, S. M. (2013) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08716.x · Cited by 535
RAF-MEK-ERK pathway in cancer evolution and treatment
Ullah, R., Yin, Q., Snell, A. H., & Wan, L. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.010 · Cited by 553
Metadata
- Authors
- Brondello, J.-M., Pouysségur, J., & McKenzie, F. R.
- Venue
- Science
- Published
- 1999-12-24
- Volume
- 286
- Issue
- 5449
- Pages
- 2514-2517
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050252881
- Cited by
- 419
- References
- 36
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brondello, J.-M., Pouysségur, J., & McKenzie, F. R. (1999). Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44 MAPK -Dependent Phosphorylation. Science. https://doi.org/10.1126/science.286.5449.2514
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
