The DOI matches its Crossref record.
Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor
Abstract
Some neurodegenerative disorders may be caused by abnormal synthesis or utilization of trophic molecules required to support neuronal survival. A test of this hypothesis requires that trophic agents specific for the affected neurons be identified. Cholinergic neurons in the corpus striatum of neonatal rats were found to respond to intracerebroventricular administration of nerve growth factor with prominent, dose-dependent, selective increases in choline acetyltransferase activity. Cholinergic neurons in the basal forebrain also respond to nerve growth factor in this way. These actions of nerve growth factor may indicate its involvement in the normal function of forebrain cholinergic neurons as well as in neurodegenerative disorders involving such cells.
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Citations
Cited by
The Nerve Growth Factor 35 Years Later
Levi-Montalcini, R. (1987) · Science · doi:10.1126/science.3306916 · Cited by 3,125
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
Hefti, F. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-08-02155.1986 · Cited by 1,450
Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair
Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284
Self-citationCholinergic systems in mammalian brain and spinal cord
WOOLF, N. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90006-m · Cited by 948
Functional Interactions of Neurotrophins and Neurotrophin Receptors
Bothwell, M. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.001255 · Cited by 833
Metadata
- Authors
- Mobley, W. C., Rutkowski, J. L., Tennekoon, G. I., Buchanan, K., & Johnston, M. V.
- Venue
- Science
- Published
- 1985-07-19
- Volume
- 229
- Issue
- 4710
- Pages
- 284-287
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023664289
- Cited by
- 480
- References
- 0
- FWCI
- 17.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor. https://app.cochat.ai/papers/10.1126/science.2861660
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- Mobley, W. C., Rutkowski, J. L., Tennekoon, G. I., Buchanan, K., & Johnston, M. V. (1985). Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor. Science. https://doi.org/10.1126/science.2861660
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
