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A Glycophospholipid Tail at the Carboxyl Terminus of the Thy-1 Glycoprotein of Neurons and Thymocytes
Abstract
Cell surface molecules of eukaryotic cells have been considered to be integrated into the membrane bilayer by a transmembrane protein sequence. The Thy-1 antigen of rodent thymocytes and brain was the first eukaryotic membrane molecule for which biochemical data clearly suggested membrane integration via a nonprotein tail. Direct evidence is now presented showing that a glycophospholipid structure is attached to the carboxyl-terminal cysteine residue and that 31 carboxyl-terminal amino acids predicted from the Thy-1 complementary DNA sequence are not present in the mature glycoprotein. These experimental results raise questions concerning signaling across a cell membrane since antibodies to Thy-1 can stimulate T lymphocytes to release lymphokines and undergo cell division.
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Cited by
Homans, S. W., Ferguson, M. A. J., Dwek, R. A., Rademacher, T. W., Anand, R., & Williams, A. F. (1988) · Nature · doi:10.1038/333269a0 · Cited by 444
Self-citationDavitz, M. A., Low, M. G., & Nussenzweig, V (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.5.1150 · Cited by 353
Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins
Caras, I. W., Davitz, M. A., Rhee, L., Weddell, G., Martin, D. W., & Nussenzweig, V. (1987) · Nature · doi:10.1038/325545a0 · Cited by 351
A year in the life of the immunoglobulin superfamily
Williams, A. F. (1987) · Immunology Today · doi:10.1016/0167-5699(87)90016-8 · Cited by 337
Self-citationDiversity of the Immunoglobulin Gene Superfamily
Hunkapiller, T., & Hood, L. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60639-2 · Cited by 290
Metadata
- Authors
- Tse, A. G. D., Barclay, A. N., Watts, A., & Williams, A. F.
- Venue
- Science
- Published
- 1985-11-29
- Volume
- 230
- Issue
- 4729
- Pages
- 1003-1008
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089102363
- Cited by
- 302
- References
- 0
- FWCI
- 19.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Glycophospholipid Tail at the Carboxyl Terminus of the Thy-1 Glycoprotein of Neurons and Thymocytes. https://app.cochat.ai/papers/10.1126/science.2865810
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- Tse, A. G. D., Barclay, A. N., Watts, A., & Williams, A. F. (1985). A Glycophospholipid Tail at the Carboxyl Terminus of the Thy-1 Glycoprotein of Neurons and Thymocytes. Science. https://doi.org/10.1126/science.2865810
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