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Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction
Abstract
The roles of phosphoinositide 3-kinase (PI3K) and phospholipase C (PLC) in chemoattractant-elicited responses were studied in mice lacking these key enzymes. PI3Kγ was required for chemoattractant-induced production of phosphatidylinositol 3,4,5-trisphosphate [PtdIns (3,4,5)P 3 ] and has an important role in chemoattractant-induced superoxide production and chemotaxis in mouse neutrophils and in production of T cell–independent antigen-specific antibodies composed of the immunoglobulin λ light chain (TI-Igλ L ). The study of the mice lacking PLC-β2 and -β3 revealed that the PLC pathways have an important role in chemoattractant-mediated production of superoxide and regulation of protein kinases, but not chemotaxis. The PLC pathways also appear to inhibit the chemotactic activity induced by certain chemoattractants and to suppress TI-Igλ L production.
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Citations
Cited by
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Manning, B. D., & Toker, A. (2017) · Cell · doi:10.1016/j.cell.2017.04.001 · Cited by 3,772
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Synthesis and Function of 3-Phosphorylated Inositol Lipids
Vanhaesebroeck, B., Leevers, S. J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P. C., Woscholski, R., Parker, P. J., & Waterfield, M. D. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.535 · Cited by 1,535
Signaling in innate immunity and inflammation
Newton, K., & Dixit, V. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006049 · Cited by 1,513
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Metadata
- Authors
- Li, Z., Jiang, H., Xie, W., Zhang, Z., Smrcka, A. V., & Wu, D.
- Venue
- Science
- Published
- 2000-02-11
- Volume
- 287
- Issue
- 5455
- Pages
- 1046-1049
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053305914
- Cited by
- 807
- References
- 0
- FWCI
- 24.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, Z., Jiang, H., Xie, W., Zhang, Z., Smrcka, A. V., & Wu, D. (2000). Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction. Science. https://doi.org/10.1126/science.287.5455.1046
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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