Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus
Abstract
The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt signal transduction pathway plays a role in a variety of human cancers. Many recent studies of Wnt signaling have provided mechanistic insight into these dual roles. Here we focus on two areas of rapid advance: (i) the machinery that regulates the stability of the key signal transducer, β-catenin, and (ii) the effect of Wnt signaling on cellular targets outside the nucleus, the actin and microtubule cytoskeletons.
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β-Catenin translocates into the nucleus, where it forms a complex with HMG box transcription factors including LEF-1 and TCF, and activates transcription of target genes.
“β-Catenin then translocates into the nucleus, where it forms a complex with the HMG box class of transcription factors, including lymphoid enhancer factor 1 (LEF-1) and T-cell factor (TCF), and activates the transcription of its target genes (5, 17, 20).”
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References 46 · Cited by 1,253
- Authors
- Peifer, M., & Polakis, P.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Genentech (US)
- Corresponding author
- Peifer, Mark
- ORCID
- Peifer, Mark
- Venue
- Science
- Published
- 2000-03-03
- Volume
- 287
- Issue
- 5458
- Pages
- 1606-1609
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091605975
- Cited by
- 1,253
- References
- 46
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 11 · 2023: 21 · 2022: 13 · 2021: 14 · 2020: 29 · 2019: 31 · 2018: 23 · 2017: 23 · 2016: 23 · 2015: 39 · 2014: 33 · 2013: 45 · 2012: 49
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, β-catenin, β-catenin stability, embryonic development, carcinogenesis, actin cytoskeleton, microtubule cytoskeleton, cell-to-cell communication, signal transduction, cell fate determination
- MeSH terms
- Animals, Cell Nucleus, Cytoskeletal Proteins, Cytoskeleton, Embryo, Nonmammalian, Embryonic and Fetal Development, Humans, Neoplasms, Proteins, Proto-Oncogene Proteins, Repressor Proteins, Signal Transduction, Trans-Activators, Body Patterning, Adenomatous Polyposis Coli Protein, Zebrafish Proteins, Embryonic Development, Wnt Proteins, beta Catenin, Axin Protein
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