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Resonant Formation of DNA Strand Breaks by Low-Energy (3 to 20 eV) Electrons
Abstract
Most of the energy deposited in cells by ionizing radiation is channeled into the production of abundant free secondary electrons with ballistic energies between 1 and 20 electron volts. Here it is shown that reactions of such electrons, even at energies well below ionization thresholds, induce substantial yields of single- and double-strand breaks in DNA, which are caused by rapid decays of transient molecular resonances localized on the DNA's basic components. This finding presents a fundamental challenge to the traditional notion that genotoxic damage by secondary electrons can only occur at energies above the onset of ionization, or upon solvation when they become a slowly reacting chemical species.
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Citations
Cited by
Mechanisms of Pulsed Laser Ablation of Biological Tissues
Vogel, A., & Venugopalan, V. (2003) · Chemical Reviews · doi:10.1021/cr010379n · Cited by 1,918
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Low energy electron-driven damage in biomolecules
Sanche, L. (2005) · The European Physical Journal D · doi:10.1140/epjd/e2005-00206-6 · Cited by 567
Self-citationAlizadeh, E., Orlando, T. M., & Sanche, L. (2015) · Annual Review of Physical Chemistry · doi:10.1146/annurev-physchem-040513-103605 · Cited by 490
Self-citationSingle, Double, and Multiple Double Strand Breaks Induced in DNA by 3−100 eV Electrons
Huels, M. A., Boudaïffa, B., Cloutier, P., Hunting, D., & Sanche, L. (2003) · Journal of the American Chemical Society · doi:10.1021/ja029527x · Cited by 448
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Metadata
- Authors
- Boudaı̈ffa, B., Cloutier, P., Hunting, D., Huels, M. A., & Sanche, L.
- Venue
- Science
- Published
- 2000-03-03
- Volume
- 287
- Issue
- 5458
- Pages
- 1658-1660
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2101608919
- Cited by
- 2,262
- References
- 0
- FWCI
- 25.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boudaı̈ffa, B., Cloutier, P., Hunting, D., Huels, M. A., & Sanche, L. (2000). Resonant Formation of DNA Strand Breaks by Low-Energy (3 to 20 eV) Electrons. Science. https://doi.org/10.1126/science.287.5458.1658
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
