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Candidate Taste Receptors in Drosophila

Open access
Clyne, Peter J., Warr, Coral G., Carlson, John R.·2000·Science

Abstract

Little is known about the molecular mechanisms of taste perception in animals, particularly the initial events of taste signaling. A large and diverse family of seven transmembrane domain proteins was identified from the Drosophila genome database with a computer algorithm that identifies proteins on the basis of structure. Eighteen of 19 genes examined were expressed in the Drosophila labellum, a gustatory organ of the proboscis. Expression was not detected in a variety of other tissues. The genes were not expressed in the labellum of a Drosophila mutant, pox-neuro 70 , in which taste neurons are eliminated. Tissue specificity of expression of these genes, along with their structural similarity, supports the possibility that the family encodes a large and divergent family of taste receptors.

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Metadata

Authors
Clyne, P. J., Warr, C. G., & Carlson, J. R.
Venue
Science
Published
2000-03-10
Volume
287
Issue
5459
Pages
1830-1834
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2079940855
Cited by
615
References
2
FWCI
7.48
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Candidate Taste Receptors in Drosophila. https://app.cochat.ai/papers/10.1126/science.287.5459.1830
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Clyne, P. J., Warr, C. G., & Carlson, J. R. (2000). Candidate Taste Receptors in Drosophila. Science. https://doi.org/10.1126/science.287.5459.1830

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.