The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Retinal Stem Cells in the Adult Mammalian Eye
Abstract
The mature mammalian retina is thought to lack regenerative capacity. Here, we report the identification of a stem cell in the adult mouse eye, which represents a possible substrate for retinal regeneration. Single pigmented ciliary margin cells clonally proliferate in vitro to form sphere colonies of cells that can differentiate into retinal-specific cell types, including rod photoreceptors, bipolar neurons, and Müller glia. Adult retinal stem cells are localized to the pigmented ciliary margin and not to the central and peripheral retinal pigmented epithelium, indicating that these cells may be homologous to those found in the eye germinal zone of other nonmammalian vertebrates.
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Citations
Cites
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
Cited by
Bringmann, A., Iandiev, I., Pannicke, T., Wurm, A., Hollborn, M., Wiedemann, P., Osborne, N. N., & Reichenbach, A. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.07.001 · Cited by 761
Molecular characterization of retinal stem cells and their niches in adult zebrafish
Raymond, P. A., Barthel, L. K., Bernardos, R. L., & Perkowski, J. J. (2006) · BMC Developmental Biology · doi:10.1186/1471-213x-6-36 · Cited by 504
Wylie, R. G., Ahsan, S., Aizawa, Y., Maxwell, K. L., Morshead, C. M., & Shoichet, M. S. (2011) · Nature Materials · doi:10.1038/nmat3101 · Cited by 480
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina
Ooto, S., Akagi, T., Kageyama, R., Akita, J., Mandai, M., Honda, Y., & Takahashi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402129101 · Cited by 454
Stem and progenitor cells: the premature desertion of rigorous definitions
Seaberg, R. M., & van der Kooy, D. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00031-6 · Cited by 371
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Metadata
- Authors
- Tropepe, V., Coles, B. L. K., Chiasson, B. J., Horsford, D. J., Elia, A. J., McInnes, R. R., & van der Kooy, D.
- Venue
- Science
- Published
- 2000-03-17
- Volume
- 287
- Issue
- 5460
- Pages
- 2032-2036
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2114268866
- Cited by
- 1,081
- References
- 2
- FWCI
- 15.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tropepe, V., Coles, B. L. K., Chiasson, B. J., Horsford, D. J., Elia, A. J., McInnes, R. R., & van der Kooy, D. (2000). Retinal Stem Cells in the Adult Mammalian Eye. Science. https://doi.org/10.1126/science.287.5460.2032
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
