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Splitting the Chromosome: Cutting the Ties That Bind Sister Chromatids
Abstract
In eukaryotic cells, sister DNA molecules remain physically connected from their production at S phase until their separation during anaphase. This cohesion is essential for the separation of sister chromatids to opposite poles of the cell at mitosis. It also permits chromosome segregation to take place long after duplication has been completed. Recent work has identified a multisubunit complex called cohesin that is essential for connecting sisters. Proteolytic cleavage of one of cohesin's subunits may trigger sister separation at the onset of anaphase.
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Citations
Cited by
Nasmyth, K. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091334 · Cited by 805
Tanaka, T. U., Rachidi, N., Janke, C., Pereira, G., Galova, M., Schiebel, E., Stark, M. J. R., & Nasmyth, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00633-5 · Cited by 722
Self-citationStuck in Division or Passing through
Rieder, C. L., & Maiato, H. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.002 · Cited by 657
The cohesin complex and its roles in chromosome biology
Peters, J.-M., Tedeschi, A., & Schmitz, J. (2008) · Genes & Development · doi:10.1101/gad.1724308 · Cited by 532
Self-citationFunctional Analysis of Kinetochore Assembly in Caenorhabditis elegans
Oegema, K., Desai, A., Rybina, S., Kirkham, M., & Hyman, A. A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.6.1209 · Cited by 428
Metadata
- Authors
- Nasmyth, K., Peters, J.-M., & Uhlmann, F.
- Venue
- Science
- Published
- 2000-05-26
- Volume
- 288
- Issue
- 5470
- Pages
- 1379-1384
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976067971
- Cited by
- 427
- References
- 0
- FWCI
- 23.88
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
