The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interdigital Regulation of Digit Identity and Homeotic Transformation by Modulated BMP Signaling
Abstract
The developmental mechanisms specifying digital identity have attracted 30 years of intense interest, but still remain poorly understood. Here, through experiments on chick foot development, we show digital identity is not a fixed property of digital primordia. Rather, digital identity is specified by the interdigital mesoderm, demonstrating a patterning function for this tissue before its regression. More posterior interdigits specify more posterior digital identities, and each primordium will develop in accordance with the most posterior cues received. Furthermore, inhibition of interdigital bone morphogenetic protein (BMP) signaling can transform digit identity, suggesting a role for BMPs in this process.
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Citations
Cites
Hox genes in digit development and evolution
Zákány, J., & Duboule, D. (1999) · Cell and Tissue Research · doi:10.1007/s004410051262 · Cited by 178
Cited by
Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis
Bandyopadhyay, A., Tsuji, K., Cox, K., Harfe, B. D., Rosen, V., & Tabin, C. J. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020216 · Cited by 624
Fgf8 signalling from the AER is essential for normal limb development
Lewandoski, M., Sun, X., & Martin, G. R. (2000) · Nature Genetics · doi:10.1038/82609 · Cited by 451
ADAMTS Metalloproteases Generate Active Versican Fragments that Regulate Interdigital Web Regression
McCulloch, D. R., Nelson, C. M., Dixon, L. J., Silver, D. L., Wylie, J. D., Lindner, V., Sasaki, T., Cooley, M. A., Argraves, W. S., & Apte, S. S. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.09.008 · Cited by 254
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
Koshiba-Takeuchi, K., Takeuchi, J. K., Arruda, E. P., Kathiriya, I. S., Mo, R., Hui, C.-C., Srivastava, D., & Bruneau, B. G. (2006) · Nature Genetics · doi:10.1038/ng1707 · Cited by 170
Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling
Suzuki, T., Takeuchi, J., Koshiba-Takeuchi, K., & Ogura, T. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00401-5 · Cited by 148
Metadata
- Authors
- Dahn, R. D., & Fallon, J. F.
- Venue
- Science
- Published
- 2000-07-21
- Volume
- 289
- Issue
- 5478
- Pages
- 438-441
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968416067
- Cited by
- 268
- References
- 1
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dahn, R. D., & Fallon, J. F. (2000). Interdigital Regulation of Digit Identity and Homeotic Transformation by Modulated BMP Signaling. Science. https://doi.org/10.1126/science.289.5478.438
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
