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A Structural Model of Transcription Elongation
Abstract
The path of the nucleic acids through a transcription elongation complex was tracked by mapping cross-links between bacterial RNA polymerase (RNAP) and transcript RNA or template DNA onto the x-ray crystal structure. In the resulting model, the downstream duplex DNA is nestled in a trough formed by the β′ subunit and enclosed on top by the β subunit. In the RNAP channel, the RNA/DNA hybrid extends from the enzyme active site, along a region of the β subunit harboring rifampicin resistance mutations, to the β′ subunit “rudder.” The single-stranded RNA is then extruded through another channel formed by the β-subunit flap domain. The model provides insight into the functional properties of the transcription complex.
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Citations
Cited by
Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase
Campbell, E. A., Korzheva, N., Mustaev, A., Murakami, K., Nair, S., Goldfarb, A., & Darst, S. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00286-0 · Cited by 1,556
Self-citationStructural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
Cramer, P., Bushnell, D. A., & Kornberg, R. D. (2001) · Science · doi:10.1126/science.1059493 · Cited by 1,247
The regulation of bacterial transcription initiation
Browning, D. F., & Busby, S. J. W. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro787 · Cited by 1,019
Multiple Sigma Subunits and the Partitioning of Bacterial Transcription Space
Gruber, T. M., & Gross, C. A. (2003) · Annual Review of Microbiology · doi:10.1146/annurev.micro.57.030502.090913 · Cited by 934
Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 Å resolution
Vassylyev, D. G., Sekine, S.-I., Laptenko, O., Lee, J., Vassylyeva, M. N., Borukhov, S., & Yokoyama, S. (2002) · Nature · doi:10.1038/nature752 · Cited by 743
Metadata
- Authors
- Korzheva, N., Mustaev, A., Kozlov, M., Malhotra, A., Nikiforov, V., Goldfarb, A., & Darst, S. A.
- Venue
- Science
- Published
- 2000-07-28
- Volume
- 289
- Issue
- 5479
- Pages
- 619-625
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052377115
- Cited by
- 402
- References
- 0
- FWCI
- 27.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Korzheva, N., Mustaev, A., Kozlov, M., Malhotra, A., Nikiforov, V., Goldfarb, A., & Darst, S. A. (2000). A Structural Model of Transcription Elongation. Science. https://doi.org/10.1126/science.289.5479.619
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
