The DOI matches its Crossref record.
Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin
Open accessAbstract
The proliferating cell nuclear antigen (PCNA or cyclin) is a nuclear protein recently identified as a cofactor of DNA polymerase δ. When exponentially growing Balb/c3T3 cells are exposed to antisense oligodeoxynucleotides to PCNA, both DNA synthesis and mitosis are completely suppressed. A corresponding sense oligodeoxynucleotide has no inhibitory effects. These experiments indicate that PCNA (cyclin) is important in cellular DNA synthesis and in cell cycle progression.
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Citations
Cited by
Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts
Pagano, M., Theodoras, A. M., Tam, S. W., & Draetta, G. F. (1994) · Genes & Development · doi:10.1101/gad.8.14.1627 · Cited by 294
D-type cyclin-binding regions of proliferating cell nuclear antigen
Matsuoka, S., Yamaguchi, M., & Matsukage, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78087-9 · Cited by 88
DNA polymerase delta: A second eukaryotic DNA replicase
Downey, K. M., Tan, C., & So, A. G. (1990) · BioEssays · doi:10.1002/bies.950120507 · Cited by 51
Metadata
- Authors
- Jaskulski, D., deRiel, J. K., Mercer, W. E., Calabretta, B., & Baserga, R.
- Venue
- Science
- Published
- 1988-06-10
- Volume
- 240
- Issue
- 4858
- Pages
- 1544-1546
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1995129870
- Cited by
- 416
- References
- 0
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin. https://app.cochat.ai/papers/10.1126/science.2897717
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- Jaskulski, D., deRiel, J. K., Mercer, W. E., Calabretta, B., & Baserga, R. (1988). Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin. Science. https://doi.org/10.1126/science.2897717
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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