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X-Chromosome Inactivation in Cloned Mouse Embryos
Abstract
To study whether cloning resets the epigenetic differences between the two X chromosomes of a somatic female nucleus, we monitored X inactivation in cloned mouse embryos. Both X chromosomes were active during cleavage of cloned embryos, followed by random X inactivation in the embryo proper. In the trophectoderm (TE), X inactivation was nonrandom with the inactivated X of the somatic donor being chosen for inactivation. When female embryonic stem cells with two active X chromosomes were used as donors, random X inactivation was seen in the TE and embryo. These results demonstrate that epigenetic marks can be removed and reestablished on either X chromosome during cloning. Our results also suggest that the epigenetic marks imposed on the X chromosomes during gametogenesis, responsible for normal imprinted X inactivation in the TE, are functionally equivalent to the marks imposed on the chromosomes during somatic X inactivation.
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Cites
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
LYON, M. F. (1961) · Nature · doi:10.1038/190372a0 · Cited by 3,978
Cited by
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
Self-citationEpigenetic Reprogramming in Mammalian Development
Reik, W., Dean, W., & Walter, J. (2001) · Science · doi:10.1126/science.1063443 · Cited by 3,078
Maherali, N., Sridharan, R., Xie, W., Utikal, J., Eminli, S., Arnold, K., Stadtfeld, M., Yachechko, R., Tchieu, J., Jaenisch, R., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.05.014 · Cited by 1,725
Self-citationCsankovszki, G., Nagy, A., & Jaenisch, R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.4.773 · Cited by 494
Self-citationMolecular features of cellular reprogramming and development
Smith, Z. D., Sindhu, C., & Meissner, A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.6 · Cited by 155
Metadata
- Authors
- Eggan, K., Akutsu, H., Hochedlinger, K., Rideout, W., Yanagimachi, R., & Jaenisch, R.
- Venue
- Science
- Published
- 2000-11-24
- Volume
- 290
- Issue
- 5496
- Pages
- 1578-1581
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2135755375
- Cited by
- 266
- References
- 1
- FWCI
- 13.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Eggan, K., Akutsu, H., Hochedlinger, K., Rideout, W., Yanagimachi, R., & Jaenisch, R. (2000). X-Chromosome Inactivation in Cloned Mouse Embryos. Science. https://doi.org/10.1126/science.290.5496.1578
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
