The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Role of ER Export Signals in Controlling Surface Potassium Channel Numbers
Abstract
Little is known about the identity of endoplasmic reticulum (ER) export signals and how they are used to regulate the number of proteins on the cell surface. Here, we describe two ER export signals that profoundly altered the steady-state distribution of potassium channels and were required for channel localization to the plasma membrane. When transferred to other potassium channels or a G protein–coupled receptor, these ER export signals increased the number of functional proteins on the cell surface. Thus, ER export of membrane proteins is not necessarily limited by folding or assembly, but may be under the control of specific export signals.
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Cites
A New ER Trafficking Signal Regulates the Subunit Stoichiometry of Plasma Membrane KATP Channels
Zerangue, N., Schwappach, B., Jan, Y. N., & Jan, L. Y. (1999) · Neuron · doi:10.1016/s0896-6273(00)80708-4 · Cited by 1,025
Self-citationProtein Oligomerization in the Endoplasmic Reticulum
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INWARD RECTIFIER POTASSIUM CHANNELS
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A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization
Margeta-Mitrovic, M., Jan, Y. N., & Jan, L. Y. (2000) · Neuron · doi:10.1016/s0896-6273(00)00012-x · Cited by 680
Self-citationA Di-Acidic Signal Required for Selective Export from the Endoplasmic Reticulum
Nishimura, N., & Balch, W. E. (1997) · Science · doi:10.1126/science.277.5325.556 · Cited by 485
COPII–cargo interactions direct protein sorting into ER-derived transport vesicles
Kuehn, M. J., Herrmann, J. M., & Schekman, R. (1998) · Nature · doi:10.1038/34438 · Cited by 409
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βSubunits Promote K+ Channel Surface Expression through Effects Early in Biosynthesis
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Protein sorting by selective retention in the endoplasmic reticulum and Golgi stack
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Independent optical excitation of distinct neural populations
Klapoetke, N. C., Murata, Y., Kim, S. S., Pulver, S. R., Birdsey-Benson, A., Cho, Y. K., Morimoto, T. K., Chuong, A. S., Carpenter, E. J., Tian, Z., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2836 · Cited by 2,344
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Whorton, M. R., & MacKinnon, R. (2011) · Cell · doi:10.1016/j.cell.2011.07.046 · Cited by 441
An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing
Scott, D. B., Blanpied, T. A., Swanson, G. T., Zhang, C., & Ehlers, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03063.2001 · Cited by 418
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Metadata
- Authors
- Ma, D., Zerangue, N., Lin, Y.-F., Collins, A., Yu, M., Jan, Y. N., & Jan, L. Y.
- Venue
- Science
- Published
- 2001-01-12
- Volume
- 291
- Issue
- 5502
- Pages
- 316-319
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2088337203
- Cited by
- 396
- References
- 14
- FWCI
- 12.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ma, D., Zerangue, N., Lin, Y.-F., Collins, A., Yu, M., Jan, Y. N., & Jan, L. Y. (2001). Role of ER Export Signals in Controlling Surface Potassium Channel Numbers. Science. https://doi.org/10.1126/science.291.5502.316
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
