The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Muscarinic Modulation of Cardiac Rate at Low Acetylcholine Concentrations
Abstract
Slowing of cardiac pacemaking induced by cholinergic input is thought to arise from the opening of potassium channels caused by muscarinic receptor stimulation. In mammalian sinoatrial node cells, however, muscarinic stimulation also inhibits the hyperpolarization-activated current ( I f ), which is involved in the generation of pacemaker activity and its acceleration by catecholamines. Acetylcholine at nanomolar concentrations inhibits I f and slows spontaneous rate, whereas 20 times higher concentrations are required to activate the acetylcholine-dependent potassium current ( I K,Ach ). Thus, modulation of I f , rather than I K,Ach , is the mechanism underlying the muscarinic control of cardiac pacing at low (nanomolar) acetylcholine concentrations.
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Citations
Cites
Changes in membrane currents in bullfrog atrium produced by acetylcholine.
Giles, W., & Noble, S. J. (1976) · The Journal of Physiology · doi:10.1113/jphysiol.1976.sp011550 · Cited by 254
Zum Mechanismus der Membranwirkung des Acetylcholin an der Herzmuskelfaser
Trautwein, W., & Dudel, J. (1958) · Pfl�gers Archiv f�r die Gesamte Physiologie des Menschen und der Tiere · doi:10.1007/bf00416781 · Cited by 249
Breitwieser, G. E., & Szabo, G. (1988) · The Journal of general physiology · doi:10.1085/jgp.91.4.469 · Cited by 203
DiFrancesco, D., & Tromba, C. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017344 · Cited by 184
Self-citationDiFrancesco, D., & Tromba, C. (1988) · The Journal of Physiology · doi:10.1113/jphysiol.1988.sp017343 · Cited by 171
Self-citationTwo Components of the Cardiac Action Potential
de Carvalho, A. P., Hoffman, B. F., & Carvalho, M. D. P. (1969) · The Journal of General Physiology · doi:10.1085/jgp.54.5.607 · Cited by 151
Acetylcholine inhibits activation of the cardiac hyperpolarizing-activated current,i f
DiFrancesco, D., & Tromba, C. (1987) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00581906 · Cited by 87
Self-citationOsterrieder, W., Noma, A., & Trautwein, W. (1980) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584196 · Cited by 82
Cited by
Direct activation of cardiac pacemaker channels by intracellular cyclic AMP
DiFrancesco, D., & Tortora, P. (1991) · Nature · doi:10.1038/351145a0 · Cited by 850
Self-citationCellular and Synaptic Adaptations Mediating Opioid Dependence
Williams, J. T., Christie, M. J., & Manzoni, O. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.299 · Cited by 848
The sinoatrial node, a heterogeneous pacemaker structure
Boyett, M. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00135-8 · Cited by 698
Lakatta, E. G., Maltsev, V. A., & Vinogradova, T. M. (2010) · Circulation Research · doi:10.1161/circresaha.109.206078 · Cited by 629
Genesis and Regulation of the Heart Automaticity
Mangoni, M. E., & Nargeot, J. (2008) · Physiological Reviews · doi:10.1152/physrev.00018.2007 · Cited by 600
Metadata
- Authors
- DiFrancesco, D., Ducouret, P., & Robinson, R. B.
- Venue
- Science
- Published
- 1989-02-03
- Volume
- 243
- Issue
- 4891
- Pages
- 669-671
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974625359
- Cited by
- 279
- References
- 8
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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