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A β 2 Adrenergic Receptor Signaling Complex Assembled with the Ca 2+ Channel Ca v 1.2
Abstract
The existence of a large number of receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) raises the question of how a particular receptor selectively regulates specific targets. We provide insight into this question by identifying a prototypical macromolecular signaling complex. The β 2 adrenergic receptor was found to be directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca v 1.2. This complex also contained a G protein, an adenylyl cyclase, cyclic adenosine monophosphate–dependent protein kinase, and the counterbalancing phosphatase PP2A. Our electrophysiological recordings from hippocampal neurons demonstrate highly localized signal transduction from the receptor to the channel. The assembly of this signaling complex provides a mechanism that ensures specific and rapid signaling by a G protein–coupled receptor.
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Citations
Cited by
Stamler (2001) · doi:10.1016/s0092-8674(01)00495-0 · Cited by 1,261
Novel Single Chain cAMP Sensors for Receptor-induced Signal Propagation
Nikolaev, V. O., Bünemann, M., Hein, L., Hannawacker, A., & Lohse, M. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400302200 · Cited by 688
Communication Between the Synapse and the Nucleus in Neuronal Development, Plasticity, and Disease
Cohen, S., & Greenberg, M. E. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175235 · Cited by 400
Regulation and organization of adenylyl cyclases and cAMP
COOPER, D. M. F. (2003) · Biochemical Journal · doi:10.1042/bj20031061 · Cited by 356
Oliveria, S. F., Dell'Acqua, M. L., & Sather, W. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.032 · Cited by 344
Metadata
- Authors
- Davare, M. A., Avdonin, V., Hall, D. D., Peden, E. M., Burette, A., Weinberg, R. J., Horne, M. C., Hoshi, T., & Hell, J. W.
- Venue
- Science
- Published
- 2001-07-06
- Volume
- 293
- Issue
- 5527
- Pages
- 98-101
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016489131
- Cited by
- 512
- References
- 0
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Davare, M. A., Avdonin, V., Hall, D. D., Peden, E. M., Burette, A., Weinberg, R. J., Horne, M. C., Hoshi, T., & Hell, J. W. (2001). A β 2 Adrenergic Receptor Signaling Complex Assembled with the Ca 2+ Channel Ca v 1.2. Science. https://doi.org/10.1126/science.293.5527.98
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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