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Selective Sparing of a Class of Striatal Neurons in Huntington's Disease
Abstract
A distinct subpopulation of striatal aspiny neurons, containing the enzyme nicotinamide adenine dinucleotide phosphate diaphorase, is preserved in the caudate nucleus in Huntington's disease. Biochemical assays confirmed a significant increase in the activity of this enzyme in both the caudate nucleus and putamen in postmortem brain tissue from patients with this disease. The resistance of these neurons suggests that the gene defect in Huntington's disease may be modifiable by the local biochemical environment. This finding may provide insight into the nature of the genetically programmed cell death that is a characteristic of the disease.
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Cited by
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Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C., Reed, R. R., & Snyder, S. H. (1991) · Nature · doi:10.1038/351714a0 · Cited by 2,354
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.
Dawson, V. L., Dawson, T. M., London, E. D., Bredt, D. S., & Snyder, S. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.14.6368 · Cited by 2,174
Neuronal NADPH diaphorase is a nitric oxide synthase.
Hope, B. T., Michael, G. J., Knigge, K. M., & Vincent, S. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2811 · Cited by 1,908
Targeted disruption of the neuronal nitric oxide synthase gene
Huang, P. L., Dawson, T. M., Bredt, D. S., Snyder, S. H., & Fishman, M. C. (1993) · Cell · doi:10.1016/0092-8674(93)90615-w · Cited by 1,303
Gases as biological messengers: nitric oxide and carbon monoxide in the brain
Dawson, T., & Snyder, S. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05147.1994 · Cited by 1,043
Metadata
- Authors
- Ferrante, R. J., Kowall, N. W., Beal, M. F., Richardson, E. P., Bird, E. D., & Martin, J. B.
- Venue
- Science
- Published
- 1985-11
- Volume
- 230
- Issue
- 4725
- Pages
- 561-563
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013063789
- Cited by
- 757
- References
- 0
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ferrante, R. J., Kowall, N. W., Beal, M. F., Richardson, E. P., Bird, E. D., & Martin, J. B. (1985). Selective Sparing of a Class of Striatal Neurons in Huntington's Disease. Science. https://doi.org/10.1126/science.2931802
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
