The DOI matches its Crossref record.
Replication Dynamics of the Yeast Genome
Abstract
Oligonucleotide microarrays were used to map the detailed topography of chromosome replication in the budding yeast Saccharomyces cerevisiae . The times of replication of thousands of sites across the genome were determined by hybridizing replicated and unreplicated DNAs, isolated at different times in S phase, to the microarrays. Origin activations take place continuously throughout S phase but with most firings near mid–S phase. Rates of replication fork movement vary greatly from region to region in the genome. The two ends of each of the 16 chromosomes are highly correlated in their times of replication. This microarray approach is readily applicable to other organisms, including humans.
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Citations
Cited by
Maintaining genome stability at the replication fork
Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786
Ivessa, A. S., Lenzmeier, B. A., Bessler, J. B., Goudsouzian, L. K., Schnakenberg, S. L., & Zakian, V. A. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00456-8 · Cited by 406
A comparative genomic view of clostridial sporulation and physiology
Paredes, C. J., Alsaker, K. V., & Papoutsakis, E. T. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1288 · Cited by 342
Extrachromosomal circular DNA is common in yeast
Møller, H. D., Parsons, L., Jørgensen, T. S., Botstein, D., & Regenberg, B. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508825112 · Cited by 296
Karras, G. I., & Jentsch, S. (2010) · Cell · doi:10.1016/j.cell.2010.02.028 · Cited by 282
Metadata
- Authors
- Raghuraman, M. K., Winzeler, E. A., Collingwood, D., Hunt, S., Wodicka, L., Conway, A., Lockhart, D. J., Davis, R. W., Brewer, B. J., & Fangman, W. L.
- Venue
- Science
- Published
- 2001-10-05
- Volume
- 294
- Issue
- 5540
- Pages
- 115-121
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008486131
- Cited by
- 793
- References
- 0
- FWCI
- 13.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Raghuraman, M. K., Winzeler, E. A., Collingwood, D., Hunt, S., Wodicka, L., Conway, A., Lockhart, D. J., Davis, R. W., Brewer, B. J., & Fangman, W. L. (2001). Replication Dynamics of the Yeast Genome. Science. https://doi.org/10.1126/science.294.5540.115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
