The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Multiple DNA-pRotein Interactions Governing High-Precision DNA Transactions
Abstract
The precise association of DNA-binding proteins with localized regions of DNA is crucial for regulated replication and expression of the genome. For certain DNA transactions, the requirement for precision in localization and control is extremely high. High-precision events amenable to detailed biochemical analysis are the initiation of DNA replication and site-specific recombination by bacteriophage λ and Escherichia coli . Recent experiments indicate that site-localization and control in these reactions involves the association of DNA-bound proteins to generate organized nucleoprotein structures in which the DNA is folded or wound. These specialized nucleoprotein structures are likely to provide the requisite accuracy for site localization and the necessary regulated reactivity to direct the DNA transaction. Multiple DNA-protein interactions are also required for controlled transcription of the eukaryotic genome. Distant upstream regulator and enhancer sequences may define protein-binding sites that form part of a reactive nucleoprotein structure capable of initiating transcription.
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Cites
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Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins
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Specific DNA binding of GAL4, a positive regulatory protein of yeast
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Cited by
Histonelike proteins of bacteria
Drlica, K., & Rouvière‐Yaniv, J. (1987) · Microbiological Reviews · doi:10.1128/mmbr.51.3.301-319.1987 · Cited by 769
A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae
Johnston, M. (1987) · Microbiological Reviews · doi:10.1128/mmbr.51.4.458-476.1987 · Cited by 745
Giese, K., Cox, J., & Grosschedl, R. (1992) · Cell · doi:10.1016/0092-8674(92)90129-z · Cited by 676
The enhanceosome and transcriptional synergy.
Carey, M. (1998) · Cell · doi:10.1016/s0092-8674(00)80893-4 · Cited by 553
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Metadata
- Authors
- Echols, H.
- Venue
- Science
- Published
- 1986-09-05
- Volume
- 233
- Issue
- 4768
- Pages
- 1050-1056
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012819319
- Cited by
- 301
- References
- 42
- FWCI
- 15.89
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
