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Cited by 370

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

A Single Receptor Binds Both Insulin-Like Growth Factor II and Mannose-6-Phosphate

MacDonald, Richard G., Pfeffer, Suzanne R., Coussens, Lisa, Tepper, Mark A., Brocklebank, Carol M., Mole, John E., Anderson, Jacqueline K., Chen, Ellson, Czech, Michael P., Ullrich, Axel·1988·Science

Abstract

Amino acid sequences deduced from rat complementary DNA clones encoding the insulin-like growth factor II (IGF-II) receptor closely resemble those of the bovine cation-independent mannose-6-phosphate receptor (Man-6-P receptor CI ), suggesting they are identical structures. It is also shown that IGF-II receptors are adsorbed by immobilized pentamannosyl-6-phosphate and are specifically eluted with Man-6-P. Furthermore, Man-6-P specifically increases by about two times the apparent affinity of the purified rat placental receptor for 125 I-labeled IGF-II. These results indicate that the type II IGF receptor contains cooperative, high-affinity binding sites for both IGF-II and Man-6-P-containing proteins.

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Crossref · 10.1126/science.2964083

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Metadata

Authors
MacDonald, R. G., Pfeffer, S. R., Coussens, L., Tepper, M. A., Brocklebank, C. M., Mole, J. E., Anderson, J. K., Chen, E., Czech, M. P., & Ullrich, A.
Venue
Science
Published
1988-03-04
Volume
239
Issue
4844
Pages
1134-1137
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2031997272
Cited by
370
References
2
FWCI
36.82
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A Single Receptor Binds Both Insulin-Like Growth Factor II and Mannose-6-Phosphate. https://app.cochat.ai/papers/10.1126/science.2964083
The paper
MacDonald, R. G., Pfeffer, S. R., Coussens, L., Tepper, M. A., Brocklebank, C. M., Mole, J. E., Anderson, J. K., Chen, E., Czech, M. P., & Ullrich, A. (1988). A Single Receptor Binds Both Insulin-Like Growth Factor II and Mannose-6-Phosphate. Science. https://doi.org/10.1126/science.2964083

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.