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Cited by 515

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The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites

Franza, B. Robert, Rauscher, Frank J., Josephs, Steven F., Curran, Tom·1988·Science

Abstract

The Fos protein complex and several Fos-related antigens bind directly or indirectly to a common sequence element that is similar to the consensus binding site for HeLa cell activator protein 1 (AP-1). This element is present in a negative regulatory sequence in the differentiation-sensitive adipocyte gene, aP2; in a transcriptional enhancer for the Gibbon ape leukemia virus; and in a region of the human immunodeficiency virus (HIV) long terminal repeat partially characterized as a negative regulatory element. The protein level and binding activity of Fos and Fos-related antigens increase rapidly after calcium ionophore treatment of a CD4 + human lymphoblast cell line, H9. These data suggest that several proteins may associate with the AP-1 binding site. Moreover, temporally regulated control of the level of each protein could represent a mechanism for modulation of these putative mediators of gene expression.

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Metadata

Authors
Franza, B. R., Rauscher, F. J., Josephs, S. F., & Curran, T.
Venue
Science
Published
1988-03-04
Volume
239
Issue
4844
Pages
1150-1153
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1969949240
Cited by
515
References
1
FWCI
31.13
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites. https://app.cochat.ai/papers/10.1126/science.2964084
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Franza, B. R., Rauscher, F. J., Josephs, S. F., & Curran, T. (1988). The Fos Complex and Fos-Related Antigens Recognize Sequence Elements That Co ntain AP-1 Binding Sites. Science. https://doi.org/10.1126/science.2964084

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