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Crystallographic and Spectroscopic Characterization of a Nonheme Fe(IV)=O Complex
Abstract
Following the heme paradigm, it is often proposed that dioxygen activation by nonheme monoiron enzymes involves an iron(IV)=oxo intermediate that is responsible for the substrate oxidation step. Such a transient species has now been obtained from a synthetic complex with a nonheme macrocyclic ligand and characterized spectroscopically. Its high-resolution crystal structure reveals an iron-oxygen bond length of 1.646(3) angstroms, demonstrating that a terminal iron(IV)=oxo unit can exist in a nonporphyrin ligand environment and lending credence to proposed mechanisms of nonheme iron catalysis.
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Citations
Cited by
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Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068
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Hausinger, R. P. (2004) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230490440541 · Cited by 937
Time-resolved observations of water oxidation intermediates on a cobalt oxide nanoparticle catalyst
Zhang, M., de Respinis, M., & Frei, H. (2014) · Nature Chemistry · doi:10.1038/nchem.1874 · Cited by 855
Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins
Clifton, I. J., McDonough, M. A., Ehrismann, D., Kershaw, N. J., Granatino, N., & Schofield, C. J. (2006) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2006.01.024 · Cited by 441
Schöneboom, J. C., Neese, F., & Thiel, W. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0424732 · Cited by 260
Metadata
- Authors
- Rohde, J.-U., In, J.-H., Lim, M. H., Brennessel, W. W., Bukowski, M. R., Stubna, A., Münck, E., Nam, W., & Que, L.
- Venue
- Science
- Published
- 2003-02-14
- Volume
- 299
- Issue
- 5609
- Pages
- 1037-1039
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012090737
- Cited by
- 929
- References
- 0
- FWCI
- 37.04
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rohde, J.-U., In, J.-H., Lim, M. H., Brennessel, W. W., Bukowski, M. R., Stubna, A., Münck, E., Nam, W., & Que, L. (2003). Crystallographic and Spectroscopic Characterization of a Nonheme Fe(IV)=O Complex. Science. https://doi.org/10.1126/science.299.5609.1037
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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