Inhibition of Lymphocyte Proliferation by a Synthetic Peptide Homologous to Retroviral Envelope Proteins
Abstract
The retroviral transmembrane envelope protein p15E is immunosuppressive in that it inhibits immune responses of lymphocytes, monocytes, and macrophages. A region of p15E has been conserved among murine and feline retroviruses; a homologous region is also found in the transmembrane envelope proteins of the human retroviruses HTLV-I and HTLV-II and in a putative envelope protein encoded by an endogenous C-type human retroviral DNA. A peptide (CKS-17) was synthesized to correspond to this region of homology and was examined for its effects on lymphocyte proliferation. CKS-17 inhibited the proliferation of an interleukin-2-dependent murine cytotoxic T-cell line as well as alloantigen-stimulated proliferation of murine and human lymphocytes. Four other peptides, representing different regions of virus proteins, were inactive. These results suggest that the immunosuppressive portion of retroviral transmembrane envelope proteins may reside, at least in part, in a-conserved sequence represented by the CKS-17 peptide.
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The ISD is relatively conserved among many different retroviruses of other species, including human.
“and was also shown to be relatively conserved among many different retroviruses of other species, including human 50,51.”
From Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis (2013) · cites this paper as [51]
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“A particular domain, termed immunosuppressive domain (ISD), has been identified within the transmembrane subunit of the envelope protein of Moloney MLV and Feline leukemia virus (FeLV), and was also shown to be relatively conserved among many different retroviruses of other species, including human [50, 51].”
BackgroundEndogenous retroviral pathogenesis in lupus
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Human Endogenous Retroviruses: Our Genomic Fossils and Companions
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- Authors
- Cianciolo, G. J., Copeland, T. D., Oroszlan, S., & Snyderman, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Frederick National Laboratory for Cancer Research (US)
- Laboratory of Immune Effector Function, Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
- Venue
- Science
- Published
- 1985-10-25
- Volume
- 230
- Issue
- 4724
- Pages
- 453-455
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971951822
- Cited by
- 451
- References
- 1
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 8 · 2022: 4 · 2021: 17 · 2020: 2 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 13 · 2012: 10
- FWCI
- 10.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ca029589-13, 5r23ca034671-03)
- National Cancer Institute (P01-CA29589-02, R23-CA34671-02)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- immunosuppression, lymphocyte proliferation inhibition, synthetic peptides, cytotoxic T lymphocytes, alloantigen stimulation, HTLV-1, HTLV-II, conserved sequences
- MeSH terms
- Amino Acid Sequence, Animals, Cell Line, Leukemia Virus, Feline, Humans, Lymphocyte Culture Test, Mixed, Lymphocyte Activation, Lymphocytes, Mice, Inbred BALB C, Leukemia Virus, Murine, Peptides, Retroviridae, Spleen, Viral Envelope Proteins, Deltaretrovirus, Intercellular Signaling Peptides and Proteins, Mice
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