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Cystic Fibrosis Locus Defined by a Genetically Linked Polymorphic DNA Marker
Abstract
A polymorphic DNA marker has been found genetically linked, in a set of 39 human families, to an autosomal recessive gene that causes cystic fibrosis (CF), a disease affecting one in 2000 Caucasian children. The DNA marker (called D0CRI-917 ) is also linked to the PON locus, which by independent evidence is linked to the CF locus. The best estimates of the genetic distances are 5 centimorgans between the DNA marker and PON and 15 centimorgans between the DNA marker and the CF locus, meaning that the location of the disease gene has been narrowed to about 1 percent of the human genome (about 30 million base pairs). Although the data are consistent with the interpretation that a single locus causes cystic fibrosis, the possibility of genetic heterogeneity remains. The discovery of a linked DNA polymorphism is the first step in molecular analysis of the CF gene and its causative role in the disease.
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Cited by
Identification of the Cystic Fibrosis Gene: Genetic Analysis
Kerem, B.-S., Rommens, J. M., Buchanan, J. A., Markiewicz, D., Cox, T. K., Chakravarti, A., Buchwald, M., & Tsui, L.-C. (1989) · Science · doi:10.1126/science.2570460 · Cited by 4,142
Self-citationThe Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21
St George-Hyslop, P. H., Tanzi, R. E., Polinsky, R. J., Haines, J. L., Nee, L., Watkins, P. C., Myers, R. H., Feldman, R. G., Pollen, D., Drachman, D., et al. (1987) · Science · doi:10.1126/science.2880399 · Cited by 1,163
(1988) · PubMed · Cited by 489
Physiological Basis of Cystic Fibrosis: A Historical Perspective
QUINTON, P. M. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.s3 · Cited by 405
Identifying Sarcomere Gene Mutations in Hypertrophic Cardiomyopathy: A Personal History
Seidman, C. E., & Seidman, J. G. (2011) · Circulation Research · doi:10.1161/circresaha.110.223834 · Cited by 271
Metadata
- Authors
- Tsui, L.-C., Buchwald, M., Barker, D., Braman, J. C., Knowlton, R., Schumm, J. W., Eiberg, H., Mohr, J., Kennedy, D., Plavsic, N., Zsiga, M., Markiewicz, D., Akots, G., Brown, V., Helms, C., Gravius, T., Parker, C., Rediker, K., & Donis-Keller, H.
- Venue
- Science
- Published
- 1985-11-29
- Volume
- 230
- Issue
- 4729
- Pages
- 1054-1057
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030423815
- Cited by
- 504
- References
- 0
- FWCI
- 73.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tsui, L.-C., Buchwald, M., Barker, D., Braman, J. C., Knowlton, R., Schumm, J. W., Eiberg, H., Mohr, J., Kennedy, D., Plavsic, N., Zsiga, M., Markiewicz, D., Akots, G., Brown, V., Helms, C., Gravius, T., Parker, C., Rediker, K., & Donis-Keller, H. (1985). Cystic Fibrosis Locus Defined by a Genetically Linked Polymorphic DNA Marker. Science. https://doi.org/10.1126/science.2997931
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