Neuroleukin: A Lymphokine Product of Lectin-Stimulated T Cells
Abstract
Neuroleukin is a lymphokine product of lectin-stimulated T cells that induces immunoglobulin secretion by cultured human peripheral blood mononuclear cells. Neuroleukin acts early in the in vitro response that leads to formation of antibody-secreting cells, but continued production of immunoglobulin by differentiated antibody-secreting cells is neuroleukin-independent. Although the factor is not directly mitogenic, cellular proliferation is a late component of the response to neuroleukin. Neuroleukin does not have B-cell growth factor (BCGF) or B-cell differentiation factor (BCDF) activity in defined assays. Neuroleukin-evoked induction of immunoglobulin secretion is both monocyte- and T-cell-dependent.
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NLK can serve as a neurotrophic growth factor.
“it was shown that NLK can serve as a neurotrophic growth factor [9]”
From Cerebrospinal fluid levels of the neurotrophic factor neuroleukin are increased in early Alzheimer’s disease, but not in cerebral amyloid angiopathy (2021) · cites this paper as [9]
Cites
Gurney, M. E., Apatoff, B. R., & Heinrich, S. P. (1986) · The Journal of cell biology · doi:10.1083/jcb.102.6.2264 · Cited by 35 · see citing works
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De Kort, A. M., Kuiperij, H. B., Alcolea, D., Kersten, I., Versleijen, A. A. M., Greenberg, S. M., Stoops, E., Schreuder, F. H. B. M., Klijn, C. J. M., Lleó, A., et al. (2021) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00899-0 · Cited by 13 · see citing works
- Authors
- Gurney, M. E., Apatoff, B. R., Spear, G. T., Baumel, M. J., Antel, J. P., Bania, M. B., & Reder, A. T.
- Affiliations
- University of Chicago (US)
- Venue
- Science
- Published
- 1986-10-31
- Volume
- 234
- Issue
- 4776
- Pages
- 574-581
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2007707744
- Cited by
- 195
- References
- 1
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 8 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 3
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (5PO1 NS24412)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Keywords
- neuroleukin, lymphokines, T cells, lectin stimulation, immunoglobulin secretion, antibody-secreting cells, peripheral blood mononuclear cells, B cell growth factor, B cell differentiation factor, T cell-dependent antibody response, cell proliferation
- MeSH terms
- Animals, B-Lymphocytes, Bone Marrow, Cell Line, Cells, Cultured, Glucose-6-Phosphate Isomerase, Growth Substances, Humans, Immunity, Cellular, Immunoglobulins, Leukemia, Lymphokines, Lymphoma, Pokeweed Mitogens, Sequence Homology, Nucleic Acid, T-Lymphocytes, Deltaretrovirus, Lectins, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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