The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Signal Transduction and Transcriptional Regulation by Glucocorticoid Receptor-LexA Fusion Proteins
Abstract
The glucocorticoid receptor regulates transcriptional initiation upon binding to its cognate hormone. A series of fusion genes was constructed to examine the mechanism of hormone-regulated transcriptional enhancement. The DNA binding domain of the bacterial LexA repressor was fused to receptor derivatives lacking the region that is necessary and sufficient for specific DNA binding and transcriptional enhancement at glucocorticoid response elements (GRE's). The resultant hybrid proteins activated transcription from promoters linked to the lex operator. Enhancement still required hormone binding by the hybrid receptor regardless of the exact positioning of the LexA binding domain within the protein. Thus, the unliganded hormone binding domain of the receptor acts as a strong but reversible inhibitor of receptor activity in a manner that is independent of the means by which the receptor recognizes DNA. The results also show directly that the receptor contains at least one "enhancement domain" other than that overlapping the GRE binding region; the second domain, enh2, occupies a region near the receptor amino terminus.
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A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Identification of a receptor for the morphogen retinoic acid
Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965
Cited by
Gene regulation by steroid hormones
Beato, M. (1989) · Cell · doi:10.1016/0092-8674(89)90237-7 · Cited by 3,383
Boija, A., Klein, I. A., Sabari, B. R., Dall’Agnese, A., Coffey, E. L., Zamudio, A. V., Li, C. H., Shrinivas, K., Manteiga, J. C., Hannett, N. M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.042 · Cited by 1,815
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
Pratt, W. B., & Toft, D. O. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0303 · Cited by 1,791
Kastner, P., Krust, A., Turcotte, B., Stropp, U., Tora, L., Gronemeyer, H., & Chambon, P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08280.x · Cited by 1,534
Danielian, P. S., White, R., Lees, J. A., & Parker, M. G. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05141.x · Cited by 803
Metadata
- Authors
- Godowski, P. J., Picard, D., & Yamamoto, K. R.
- Venue
- Science
- Published
- 1988-08-12
- Volume
- 241
- Issue
- 4867
- Pages
- 812-816
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2010234214
- Cited by
- 253
- References
- 2
- FWCI
- 20.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Godowski, P. J., Picard, D., & Yamamoto, K. R. (1988). Signal Transduction and Transcriptional Regulation by Glucocorticoid Receptor-LexA Fusion Proteins. Science. https://doi.org/10.1126/science.3043662
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