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Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens
Abstract
Three novel monoclonal antibodies (designated OKT1, OKT3, and OKT4) were generated against surface determinants of human peripheral T cells. Both OKT1 and OKT3 reacted with all human peripheral T cells and 5 to 10 percent of thymocytes but differed in their reactivities with T cell lines. By contrast, OKT4 reacted with 55 percent of human peripheral T cells and 80 percent of thymocytes. All three antibodies were selective for T cells in the peripheral blood in that they did not react with normal B cells, null cells, monocytes, or granulocytes.
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Citations
Cited by
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Dave, V. (1998) · International Immunology · doi:10.1093/intimm/10.10.1481 · Cited by 8
Metadata
- Authors
- Kung, P. C., Goldstein, G., Reinherz, E. L., & Schlossman, S. F.
- Venue
- Science
- Published
- 1979-10-19
- Volume
- 206
- Issue
- 4416
- Pages
- 347-349
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027922729
- Cited by
- 1,453
- References
- 0
- FWCI
- 48.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens. https://app.cochat.ai/papers/10.1126/science.314668
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- Kung, P. C., Goldstein, G., Reinherz, E. L., & Schlossman, S. F. (1979). Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens. Science. https://doi.org/10.1126/science.314668
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