The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma
Abstract
Structural changes of the human retinoblastoma gene have been demonstrated previously in retinoblastoma and some clinically related tumors including osteosarcoma. Structural aberrations of the retinoblastoma locus (RB1) were observed in 25% of breast tumor cell lines studied and 7% of the primary tumors. These changes include homozygous internal deletions and total deletion of RB1; a duplication of an exon was observed in one of the cell lines. In all cases, structural changes either resulted in the absence or truncation of the RB1 transcript. No obvious defect in RB1 was detected by DNA blot analysis in primary tumors or cell lines from Wilms' tumor, cervical carcinoma, or hepatoma. These results further support the concept that the human RB1 gene has pleiotropic effects on specific types of cancer.
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Citations
Cites
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Self-citationLoss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma
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Cited by
Localization of a Breast Cancer Susceptibility Gene, BRCA2 , to Chromosome 13q12-13
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The Rb/E2F pathway: expanding roles and emerging paradigms
Harbour, J. W., & Dean, D. C. (2000) · Genes & Development · doi:10.1101/gad.813200 · Cited by 1,153
The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
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Metadata
- Authors
- T'Ang, A., Varley, J. M., Chakraborty, S., Murphree, A. L., & Fung, Y.-K. T.
- Venue
- Science
- Published
- 1988-10-14
- Volume
- 242
- Issue
- 4876
- Pages
- 263-266
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052878543
- Cited by
- 403
- References
- 23
- FWCI
- 21.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- T'Ang, A., Varley, J. M., Chakraborty, S., Murphree, A. L., & Fung, Y.-K. T. (1988). Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma. Science. https://doi.org/10.1126/science.3175651
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
