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Astrocytes Synthesize Angiotensinogen in Brain
Abstract
Cell types associated with angiotensinogen mRNA in rat brain were identified in individual brain sections by in situ hybridization with tritiated RNA probes or with a sulfur-35—labeled oligonucleotide combined with immunocytochemical detection of either glial fibrillary acidic protein (GFAP) for astrocytes or microtubule-associated protein (MAP-2) for neurons. Autoradiography revealed silver grains clustered primarily over GFAP-reactive soma and processes; most grain clusters were not associated with MAP-2—reactive cells. These results demonstrate that, in contrast to other known neuropeptide precursors, angiotensinogen is synthesized by glia.
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Citations
Cited by
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Neuroendocrine Control of Body Fluid Metabolism
ANTUNES-RODRIGUES, J., DE CASTRO, M., ELIAS, L. L. K., VALENÇA, M. M., & McCANN, S. M. (2004) · Physiological Reviews · doi:10.1152/physrev.00017.2003 · Cited by 468
Levels of angiotensin and molecular biology of the tissue renin angiotensin systems
Ian Phillips, M., Speakman, E. A., & Kimura, B. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90403-u · Cited by 329
Neural Control of Renal Function
Johns, E. J., Kopp, U. C., & DiBona, G. F. (2011) · Comprehensive Physiology · doi:10.1002/cphy.c100043 · Cited by 278
Regulatory role of brain angiotensins in the control of physiological and behavioral responses
Wright, J. W., & Harding, J. W. (1992) · Brain Research Reviews · doi:10.1016/0165-0173(92)90018-h · Cited by 276
Metadata
- Authors
- Stornetta, R. L., Hawelu-Johnson, C. L., Guyenet, P. G., & Lynch, K. R.
- Venue
- Science
- Published
- 1988-12-09
- Volume
- 242
- Issue
- 4884
- Pages
- 1444-1446
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037773920
- Cited by
- 336
- References
- 0
- FWCI
- 9.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stornetta, R. L., Hawelu-Johnson, C. L., Guyenet, P. G., & Lynch, K. R. (1988). Astrocytes Synthesize Angiotensinogen in Brain. Science. https://doi.org/10.1126/science.3201232
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
