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Calicheamicin γ 1 I : an Antitumor Antibiotic That Cleaves Double-Stranded DNA Site Specifically
Abstract
Calicheamicin γ 1 I is a recently discovered diyne-ene—containing antitumor antibiotic with considerable potency against murine tumors. In vitro, this drug interacts with double-helical DNA in the minor groove and causes site-specific double-stranded cleavage. It is proposed that the observed cleavage specificity is a result of a unique fit of the drug and DNA followed by the generation of a nondiffusible 1,4-dehydrobenzene—diradical species that initiates oxidative strand scission by hydrogen abstraction on the deoxyribose ring. The ability of calicheamicin γ 1 I to cause double-strand cuts at very low concentrations may account for its potent antitumor activity.
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Metadata
- Authors
- Zein, N., Sinha, A. M., McGahren, W. J., & Ellestad, G. A.
- Venue
- Science
- Published
- 1988-05-27
- Volume
- 240
- Issue
- 4856
- Pages
- 1198-1201
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043873747
- Cited by
- 565
- References
- 0
- FWCI
- 29.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zein, N., Sinha, A. M., McGahren, W. J., & Ellestad, G. A. (1988). Calicheamicin γ 1 I : an Antitumor Antibiotic That Cleaves Double-Stranded DNA Site Specifically. Science. https://doi.org/10.1126/science.3240341
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
