The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca 2+ -Mediated Endonuclease Activation
Abstract
Suspensions of thymocytes from young rats were incubated with 2,3,7,8- tetrachlorodibenzo- p -dioxin (TCDD), which resulted in a sustained increase in cytosolic free Ca 2+ concentration followed by DNA fragmentation and loss of cell viability. Both the Ca 2+ increase and DNA fragmentation were prevented in cells treated with the inhibitor of protein synthesis, cycloheximide, and DNA fragmentation and cell killing were not detected when cells were incubated in a "Ca 2+ -free" medium or pretreated with high concentrations of the calcium probe, quin-2 tetraacetoxymethyl ester. These results indicate that TCDD can kill immature thymocytes by initiating a suicide process similar to that previously described for glucocorticoid hormones.
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Cites
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
Poland, A., Glover, E., & Kende, A. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33205-2 · Cited by 1,370
Cited by
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The role of DNA fragmentation in apoptosis
Bortner, C. D., Oldenburg, N. B. E., & Cidlowski, J. A. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)88932-1 · Cited by 608
Programmed Cell Death in the Immune System
Cohen, J. J. (1991) · Advances in Immunology · doi:10.1016/s0065-2776(08)60822-6 · Cited by 560
NEBERT, D. W., PUGA, A., & VASILIOU, V. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb35928.x · Cited by 423
Targets for Dioxin: Genes for Plasminogen Activator Inhibitor-2 and Interleukin-1β
Sutter, T. R., Guzman, K., Dold, K. M., & Greenlee, W. F. (1991) · Science · doi:10.1126/science.1925598 · Cited by 337
Metadata
- Authors
- McConkey, D. J., Hartzell, P., Duddy, S. K., Håkansson, H., & Orrenius, S.
- Venue
- Science
- Published
- 1988-10-14
- Volume
- 242
- Issue
- 4876
- Pages
- 256-259
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971776926
- Cited by
- 450
- References
- 2
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: 2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca 2+ -Mediated Endonuclease Activation. https://app.cochat.ai/papers/10.1126/science.3262923
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- McConkey, D. J., Hartzell, P., Duddy, S. K., Håkansson, H., & Orrenius, S. (1988). 2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca 2+ -Mediated Endonuclease Activation. Science. https://doi.org/10.1126/science.3262923
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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