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Genetic Analysis of the Human Malaria Parasite Plasmodium falciparum
Abstract
Malaria parasites are haploid for most of their life cycle, with zygote formation and meiosis occurring during the mosquito phase of development. The parasites can be analyzed genetically by transmitting mixtures of cloned parasites through mosquitoes to permit cross-fertilization of gametes to occur. A cross was made between two clones of Plasmodium falciparum differing in enzymes, drug sensitivity, antigens, and chromosome patterns. Parasites showing recombination between the parent clone markers were detected at a high frequency. Novel forms of certain chromosomes, detected by pulsed-field gradient gel electrophoresis, were produced readily, showing that extensive rearrangements occur in the parasite genome after cross-fertilization. Since patients are frequently infected with mixtures of genetically distinct parasites, mosquito transmission is likely to provide the principal mechanisms for generating parasites with novel genotypes.
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Cited by
Salanti, A., Staalsoe, T., Lavstsen, T., Jensen, A. T. R., Sowa, M. P. K., Arnot, D. E., Hviid, L., & Theander, T. G. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03570.x · Cited by 702
Hoffman, S. L., Goh, L. M. L., Luke, T. C., Schneider, I., Le, T. P., Doolan, D. L., Sacci, J., de la Vega, P., Dowler, M., Paul, C., et al. (2002) · The Journal of Infectious Diseases · doi:10.1086/339409 · Cited by 688
A transcriptional switch underlies commitment to sexual development in malaria parasites
Kafsack, B. F. C., Rovira-Graells, N., Clark, T. G., Bancells, C., Crowley, V. M., Campino, S. G., Williams, A. E., Drought, L. G., Kwiatkowski, D. P., Baker, D. A., et al. (2014) · Nature · doi:10.1038/nature12920 · Cited by 537
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
Manske, M., Miotto, O., Campino, S., Auburn, S., Almagro-Garcia, J., Maslen, G., O’Brien, J., Djimde, A., Doumbo, O., Zongo, I., et al. (2012) · Nature · doi:10.1038/nature11174 · Cited by 486
Peterson, D. S., Milhous, W. K., & Wellems, T. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.8.3018 · Cited by 419
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Metadata
- Authors
- Walliker, D., Quakyi, I. A., Wellems, T. E., McCutchan, T. F., Szarfman, A., London, W. T., Corcoran, L. M., Burkot, T. R., & Carter, R.
- Venue
- Science
- Published
- 1987-06-26
- Volume
- 236
- Issue
- 4809
- Pages
- 1661-1666
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980752431
- Cited by
- 742
- References
- 0
- FWCI
- 39.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Walliker, D., Quakyi, I. A., Wellems, T. E., McCutchan, T. F., Szarfman, A., London, W. T., Corcoran, L. M., Burkot, T. R., & Carter, R. (1987). Genetic Analysis of the Human Malaria Parasite Plasmodium falciparum. Science. https://doi.org/10.1126/science.3299700
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