The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Neurosteroids: Cytochrome P-450 scc in Rat Brain
Abstract
The steroid hormones corticosterone and testosterone are supplied to the central nervous system by endocrine glands, the adrenals and gonads. In contrast, the 3β-hydroxy-Δ5-derivatives of cholesterol, pregnenolone and dehydroepiandrosterone, accumulate in the rat brain through mechanisms independent of peripheral sources. Immunohistochemical studies have been performed with specific antibodies to bovine adrenal cytochrome P-450 scc , which is involved in cholesterol side-chain cleavage and pregnenolone formation. The enzyme was localized in the white matter throughout the brain. Scarce clusters of cell bodies were also stained in the entorhinal and cingulate cortex and in the olfactory bulb. These observations strongly support the existence of "neurosteroids," which have been posited on the basis of biochemical, physiological, and behavioral studies.
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Cites
Pregnenolone and its sulfate ester in the rat brain
Corpéchot, C., Synguelakis, M., Talha, S., Axelson, M., Sjövall, J., Vihko, R., Baulieu, E.-E., & Robel, P. (1983) · Brain Research · doi:10.1016/0006-8993(83)90797-7 · Cited by 385
Neuro-steroids: 3β-hydroxy-Δ5-derivatives in rat and monkey brain.
Robel, P., Bourreau, E., Corpéchot, C., Dang, D. C., Halberg, F., Clarke, C., Haug, M., Schlegel, M. L., Synguelakis, M., Vourch, C., et al. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90133-6 · Cited by 175
Cited by
NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAIN
Baulieu, E. E. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00071-7 · Cited by 622
Self-citationProgesterone synthesis and myelin formation by Schwann cells
Koenig, H. L., Schumacher, M., Ferzaz, B., Thi, A. N. D., Ressouches, A., Guennoun, R., Jung-Testas, I., Robel, P., Akwa, Y., & Baulieu, E.-E. (1995) · Science · doi:10.1126/science.7770777 · Cited by 480
Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it
Flood, J. F., Morley, J. E., & Roberts, E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1567 · Cited by 436
The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor
Majewska, M. D., Demirgo¨ren, S., Spivak, C. E., & London, E. D. (1990) · Brain Research · doi:10.1016/0006-8993(90)90261-9 · Cited by 433
Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain
Mellon, S. H., & Deschepper, C. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)91332-m · Cited by 398
Metadata
- Authors
- Le Goascogne, C., Robel, P., Gouézou, M., Sananes, N., Baulieu, E.-E., & Waterman, M.
- Venue
- Science
- Published
- 1987-09-04
- Volume
- 237
- Issue
- 4819
- Pages
- 1212-1215
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031410274
- Cited by
- 363
- References
- 2
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
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