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Posttranslational Covalent Modification of Proteins: Only 20 amino acids are used in. protein synthesis, yet some 140 "amino acids" are found in various proteins.
Abstract
A search for derivatized amino acids in proteins has shown that the extent of posttranslational modification of proteins is quite substantial. While only 20 primary amino acids are specified in the genetic code and are involved as monomer building blocks in the assembly of the polypeptide chain, about 140 amino acids and amino acid derivatives have been identified as constituents of different proteins in different organisms. A brief consideration of the questions about where and when the derivatization reactions occur, how the specificity of the reactions is established, and how the posttranslational modifications can facilitate biological processes, reveal a need for more information on all these points. Answers to these questions should represent significant contributions to our understanding of biochemistry and cell biology.
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Cited by
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An amplified sensitivity arising from covalent modification in biological systems.
Goldbeter, A., & Koshland, D. E. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.6840 · Cited by 1,206
Wells, L., Vosseller, K., Cole, R. N., Cronshaw, J. M., Matunis, M. J., & Hart, G. W. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200048-mcp200 · Cited by 420
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Metadata
- Authors
- Uy, R., & Wold, F.
- Venue
- Science
- Published
- 1977-12-02
- Volume
- 198
- Issue
- 4320
- Pages
- 890-896
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070526549
- Cited by
- 372
- References
- 0
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Posttranslational Covalent Modification of Proteins: Only 20 amino acids are used in. protein synthesis, yet some 140 "amino acids" are found in various proteins. https://app.cochat.ai/papers/10.1126/science.337487
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- Uy, R., & Wold, F. (1977). Posttranslational Covalent Modification of Proteins: Only 20 amino acids are used in. protein synthesis, yet some 140 "amino acids" are found in various proteins. Science. https://doi.org/10.1126/science.337487
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
