The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA Motif
Abstract
An octamer DNA sequence plays a critical role in directing transcription of immunoglobulin genes in B lymphocytes. A new technique of direct binding of radioactive DNA was used to screen a complementary DNA expression library from the BJAB cell line in λgt11 phage to derive molecular cDNA clones representing a putative B lymphocyte-specific octamer binding protein. The plaques were screened with DNA containing four copies of the octamer sequence and positive phage recombinants were identified. The fusion protein produced on inducing a lysogen of one phage bound to a monomeric octamer probe. The cDNA insert from this phage hybridized to messenger RNA found in B lymphocytes, but not in most other cells. Thus, this cDNA derives from a gene ( oct-2 ) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell-specific transcription factor exists and its amount is controlled through messenger RNA availability.
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Cites
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Self-citationA lymphoid-specific protein binding to the octamer motif of immunoglobulin genes
Staudt, L. M., Singh, H., Sen, R., Wirth, T., Sharp, P. A., & Baltimore, D. (1986) · Nature · doi:10.1038/323640a0 · Cited by 658
Self-citationSingh, H., LeBowitz, J. H., Baldwin, A. S., & Sharp, P. A. (1988) · Cell · doi:10.1016/s0092-8674(88)80034-5 · Cited by 627
Self-citationFalkner, F. G., & Zachau, H. G. (1984) · Nature · doi:10.1038/310071a0 · Cited by 607
Protein-Binding Sites in Ig Gene Enhancers Determine Transcriptional Activity and Inducibility
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Cited by
Murre, C., McCaw, P. S., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90682-x · Cited by 2,635
Self-citationThe macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
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The structure and function of the homeodomain
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The transcriptional control of hematopoiesis [see comments]
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Metadata
- Authors
- Staudt, L. M., Clerc, R. G., Singh, H., LeBowitz, J. H., Sharp, P. A., & Baltimore, D.
- Venue
- Science
- Published
- 1988-07-29
- Volume
- 241
- Issue
- 4865
- Pages
- 577-580
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051254858
- Cited by
- 289
- References
- 30
- FWCI
- 15.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Staudt, L. M., Clerc, R. G., Singh, H., LeBowitz, J. H., Sharp, P. A., & Baltimore, D. (1988). Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA Motif. Science. https://doi.org/10.1126/science.3399892
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
