The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Ligase-Mediated Gene Detection Technique
Abstract
An assay for the presence of given DNA sequences has been developed, based on the ability of two oligonucleotides to anneal immediately adjacent to each other on a complementary target DNA molecule. The two oligonucleotides are then joined covalently by the action of a DNA ligase, provided that the nucleotides at the junction are correctly base-paired. Thus single nucleotide substitutions can be distinguished. This strategy permits the rapid and standardized identification of single-copy gene sequences in genomic DNA.
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Cites
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
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Goodwin, S., McPherson, J. D., & McCombie, W. R. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.49 · Cited by 4,352
Orita, M., Suzuki, Y., Sekiya, T., & Hayashi, K. (1989) · Genomics · doi:10.1016/0888-7543(89)90129-8 · Cited by 3,434
Museum of spatial transcriptomics
Moses, L., & Pachter, L. (2022) · Nature Methods · doi:10.1038/s41592-022-01409-2 · Cited by 1,255
Accessing genetic variation: genotyping single nucleotide polymorphisms
Syvänen, A.-C. (2001) · Nature Reviews Genetics · doi:10.1038/35103535 · Cited by 1,083
Metadata
- Authors
- Landegren, U., Kaiser, R., Sanders, J., & Hood, L.
- Venue
- Science
- Published
- 1988-08-26
- Volume
- 241
- Issue
- 4869
- Pages
- 1077-1080
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2088661249
- Cited by
- 828
- References
- 1
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Landegren, U., Kaiser, R., Sanders, J., & Hood, L. (1988). A Ligase-Mediated Gene Detection Technique. Science. https://doi.org/10.1126/science.3413476
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
