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Cited by 4,328

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Models for the Specific Adhesion of Cells to Cells: A theoretical framework for adhesion mediated by reversible bonds between cell surface molecules.

Bell, George I.·1978·Science

Abstract

A theoretical framework is proposed for the analysis of adhesion between cells or of cells to surfaces when the adhesion is mediated by reversible bonds between specific molecules such as antigen and antibody, lectin and carbohydrate, or enzyme and substrate. From a knowledge of the reaction rates for reactants in solution and of their diffusion constants both in solution and on membranes, it is possible to estimate reaction rates for membrane-bound reactants. Two models are developed for predicting the rate of bond formation between cells and are compared with experiments. The force required to separate two cells is shown to be greater than the expected electrical forces between cells, and of the same order of magnitude as the forces required to pull gangliosides and perhaps some integral membrane proteins out of the cell membrane.

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Crossref · 10.1126/science.347575

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Metadata

Authors
Bell, G. I.
Venue
Science
Published
1978-05-12
Volume
200
Issue
4342
Pages
618-627
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2052192720
Cited by
4,328
References
1
FWCI
7.84
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Models for the Specific Adhesion of Cells to Cells: A theoretical framework for adhesion mediated by reversible bonds between cell surface molecules. https://app.cochat.ai/papers/10.1126/science.347575
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Bell, G. I. (1978). Models for the Specific Adhesion of Cells to Cells: A theoretical framework for adhesion mediated by reversible bonds between cell surface molecules. Science. https://doi.org/10.1126/science.347575

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.