Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,182

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Transforming Growth Factor-β: Biological Function and Chemical Structure

Sporn, Michael B., Roberts, Anita B., Wakefield, Lalage M., Assoian, Richard K.·1986·Science
DOI 10.1126/science.3487831
Open this paper in CoChat — free account

Abstract

Transforming growth factor-β (TGF-β) is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-β and essentially all of them have specific receptors for this peptide. TGF-β regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. Its marked ability to enhance formation of connective tissue in vivo suggests several therapeutic applications.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.3487831

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Research works printed but not linked: 61

  1. Adashi E. Y. papers to be Xresented at 6th Biennial Ovarian Workshop Ithaca NY July (1986).
  2. ANZANO, M.A., ANCHORAGE-INDEPENDENT GROWTH OF PRIMARY RAT EMBRYO CELLS IS INDUCED BY PLATELET-DERIVED GROWTH-FACTOR AND INHIBITED BY TYPE-BETA TRANSFORMING GROWTH-FACTOR, JOURNAL OF CELLULAR PHYSIOLOGY 126: 312 (1986). · DOI
  3. ANZANO, M.A., INCREASED SECRETION OF TYPE-BETA TRANSFORMING GROWTH-FACTOR ACCOMPANIES VIRAL TRANSFORMATION OF CELLS, MOLECULAR AND CELLULAR BIOLOGY 5: 242 (1985).
  4. ASSOIAN, R.K., TRANSFORMING GROWTH FACTOR-BETA IN HUMAN-PLATELETS - IDENTIFICATION OF A MAJOR STORAGE SITE, PURIFICATION, AND CHARACTERIZATION, JOURNAL OF BIOLOGICAL CHEMISTRY 258: 7155 (1983). · DOI · Paper page
  5. ASSOIAN, R.K., TYPE-BETA TRANSFORMING GROWTH-FACTOR IN HUMAN-PLATELETS - RELEASE DURING PLATELET DEGRANULATION AND ACTION ON VASCULAR SMOOTH-MUSCLE CELLS, JOURNAL OF CELL BIOLOGY 102: 1217 (1986). · DOI · Paper page
  6. BOERNER, P, STIMULATION OF GLYCOLYSIS AND AMINO-ACID UPTAKE IN NRK-49F CELLS BY TRANSFORMING GROWTH FACTOR-BETA AND EPIDERMAL GROWTH-FACTOR, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 1350 (1985).
  7. Budzik, G. P., Deveopmental Mechanisms: Normal and Abnormal: 207 (1985).
  8. CATE, R.L., ISOLATION OF THE BOVINE AND HUMAN GENES FOR MULLERIAN INHIBITING SUBSTANCE AND EXPRESSION OF THE HUMAN-GENE IN ANIMAL-CELLS, CELL 45: 685 (1986). · DOI · Paper page
  9. Childs, C. B., Proceedings of the National Academy of Sciences of the United States of America 79: 5312 (1982).
  10. DERYNCK, R, HUMAN TRANSFORMING GROWTH FACTOR-BETA COMPLEMENTARY-DNA SEQUENCE AND EXPRESSION IN NORMAL AND TRANSFORMED-CELLS, NATURE 316: 701 (1985). · DOI · Paper page
  11. DODSON, W.C., ENDOCRINOLOGY 118 Supplement: 290 (1986).
  12. DONAHOE, P.K., MULLERIAN INHIBITING SUBSTANCE INHIBITS GROWTH OF A HUMAN OVARIAN-CANCER IN NUDE-MICE, ANNALS OF SURGERY 194: 472 (1981). · doi:10.1097/00000658-198110000-00010
  13. FANGER, B.O., STRUCTURE AND PROPERTIES OF THE CELLULAR RECEPTOR FOR TRANSFORMING GROWTH-FACTOR TYPE-BETA, BIOCHEMISTRY 25: 3083 (1986). · DOI
  14. FINE, L.G., BSC-1 GROWTH INHIBITOR TRANSFORMS A MITOGENIC STIMULUS INTO A HYPERTROPHIC STIMULUS FOR RENAL PROXIMAL TUBULAR CELLS - RELATIONSHIP TO NA+/H+ ANTIPORT ACTIVITY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 6163 (1985).
  15. FROLIK, C.A., CHARACTERIZATION OF A MEMBRANE-RECEPTOR FOR TRANSFORMING GROWTH FACTOR-BETA IN NORMAL RAT-KIDNEY FIBROBLASTS, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 10995 (1984). · DOI · Paper page
  16. Frolik, C. A., Proceedings of the National Academy of Sciences of the United States of America 80: 3676 (1983).
  17. Green, H., Cell 1: 113 (1974). · DOI · Paper page
  18. HAYASHI, I, DNA-SYNTHESIS IN RAT HEPATOCYTES - INHIBITION BY A PLATELET FACTOR AND STIMULATION BY AN ENDOGENOUS FACTOR, JOURNAL OF CELLULAR PHYSIOLOGY 125: 82 (1985). · DOI
  19. Holley, R. W., Proceedings of the National Academy of Sciences of the United States of America 77: 5989 (1980).
  20. HOTTA, M, ENDOCRINOLOGY 118 Supplement: 289 (1986).
  21. IGNOTZ, R.A., TRANSFORMING GROWTH-FACTOR-BETA STIMULATES THE EXPRESSION OF FIBRONECTIN AND COLLAGEN AND THEIR INCORPORATION INTO THE EXTRACELLULAR-MATRIX, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 4337 (1986). · DOI · Paper page
  22. IGNOTZ, R.A., TYPE-BETA TRANSFORMING GROWTH-FACTOR CONTROLS THE ADIPOGENIC DIFFERENTIATION OF 3T3 FIBROBLASTS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 8530 (1985).
  23. INMAN, W.H., STIMULATION OF GLUCOSE-UPTAKE BY TRANSFORMING GROWTH FACTOR-BETA - EVIDENCE FOR THE REQUIREMENT OF EPIDERMAL GROWTH-FACTOR RECEPTOR ACTIVATION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 1346 (1985).
  24. JOSSO, N, The Antimüllerian Hormone, RECENT PROGRESS IN HORMONE RESEARCH 33: 117 (1977).
  25. KEHRL, J. H., CLINICAL RESEARCH 33: A610 (1985).
  26. 10.1084/jem.163.5.1037 · DOI · Paper page
  27. KNECHT, M, ENDOCRINOLOGY 118 Supplement: 69 (1986). · DOI
  28. KRYCEVEMARTINERIE, C, FURTHER STUDY OF BETA-TGFS RELEASED BY VIRALLY TRANSFORMED AND NON-TRANSFORMED CELLS, INTERNATIONAL JOURNAL OF CANCER 35: 553 (1985). · DOI
  29. LECHNER, J.F., DIFFERENTIAL CONTROL BY PLATELET FACTORS OF SQUAMOUS DIFFERENTIATION IN NORMAL AND MALIGNANT HUMAN BRONCHIAL EPITHELIAL-CELLS, CANCER RESEARCH 43: 5915 (1983).
  30. LING, N, ISOLATION AND PARTIAL CHARACTERIZATION OF A MR 32,000 PROTEIN WITH INHIBIN ACTIVITY FROM PORCINE FOLLICULAR-FLUID, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 7217 (1985).
  31. Lucas R. C. R. & D. Systems Technical Bulletin (1985).
  32. Marquardt, H., Proceedings of the National Academy of Sciences of the United States of America 80: 4684 (1983).
  33. MASON, A.J., COMPLEMENTARY-DNA SEQUENCES OF OVARIAN FOLLICULAR-FLUID INHIBIN SHOW PRECURSOR STRUCTURE AND HOMOLOGY WITH TRANSFORMING GROWTH FACTOR-BETA, NATURE 318: 659 (1985). · DOI · Paper page
  34. MASSAGUE, J, CANCER CELL 3: 73 (1985).
  35. MASSAGUE, J, TYPE-BETA TRANSFORMING GROWTH-FACTOR FROM FELINE SARCOMA VIRUS-TRANSFORMED RAT-CELLS - ISOLATION AND BIOLOGICAL PROPERTIES, JOURNAL OF BIOLOGICAL CHEMISTRY 259: 9756 (1984). · DOI
  36. MASSAGUE, J, CELLULAR RECEPTORS FOR TYPE-BETA TRANSFORMING GROWTH-FACTOR - LIGAND-BINDING AND AFFINITY LABELING IN HUMAN AND RODENT CELL-LINES, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 2636 (1985). · DOI · Paper page
  37. MASSAGUE, J, SUBUNIT STRUCTURE OF A HIGH-AFFINITY RECEPTOR FOR TYPE BETA-TRANSFORMING GROWTH-FACTOR - EVIDENCE FOR A DISULFIDE-LINKED GLYCOSYLATED RECEPTOR COMPLEX, JOURNAL OF BIOLOGICAL CHEMISTRY 260: 7059 (1985). · DOI
  38. MASUI, T, TYPE-BETA TRANSFORMING GROWTH-FACTOR IS THE PRIMARY DIFFERENTIATION-INDUCING SERUM FACTOR FOR NORMAL HUMAN BRONCHIAL EPITHELIAL-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 2438 (1986).
  39. McMahon, J. B., Cancer Research 46: 4665 (1986).
  40. MOSES, H.L., CANCER CELL 3: 65 (1985).
  41. Pierschbacher, M. D., Proceedings of the National Academy of Sciences of the United States of America 81: 5985 (1984).
  42. RACKER, E, GLYCOLYSIS AND METHYLAMINOISOBUTYRATE UPTAKE IN RAT-1 CELLS TRANSFECTED WITH RAS OR MYC ONCOGENES, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 3535 (1985).
  43. ROBERTS, A.B., PURIFICATION AND PROPERTIES OF A TYPE BETA-TRANSFORMING GROWTH-FACTOR FROM BOVINE KIDNEY, BIOCHEMISTRY 22: 5692 (1983). · DOI · Paper page
  44. ROBERTS, A.B., TRANSFORMING GROWTH-FACTORS FROM NEOPLASTIC AND NON-NEOPLASTIC TISSUES, FEDERATION PROCEEDINGS 42: 2621 (1983).
  45. ROBERTS, A.B., SELECTIVE-INHIBITION OF THE ANCHORAGE-INDEPENDENT GROWTH OF MYC-TRANSFECTED FIBROBLASTS BY RETINOIC ACID, NATURE 315: 237 (1985). · DOI
  46. ROBERTS, A.B., TRANSFORMING GROWTH-FACTOR TYPE-BETA - RAPID INDUCTION OF FIBROSIS AND ANGIOGENESIS INVIVO AND STIMULATION OF COLLAGEN FORMATION INVITRO, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 83: 4167 (1986).
  47. Roberts, A. B., Proceedings of the National Academy of Sciences of the United States of America 78: 5339 (1981).
  48. ROBERTS, A.B., TYPE-BETA TRANSFORMING GROWTH-FACTOR - A BIFUNCTIONAL REGULATOR OF CELLULAR GROWTH, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 119 (1985).
  49. ROOK, A.H., EFFECTS OF TRANSFORMING GROWTH-FACTOR-BETA ON THE FUNCTIONS OF NATURAL-KILLER-CELLS - DEPRESSED CYTOLYTIC ACTIVITY AND BLUNTING OF INTERFERON RESPONSIVENESS, JOURNAL OF IMMUNOLOGY 136: 3916 (1986). · DOI · Paper page
  50. ROSS, R, FIBROBLAST AND WOUND REPAIR, BIOLOGICAL REVIEWS OF THE CAMBRIDGE PHILOSOPHICAL SOCIETY 43: 51 (1968). · DOI · Paper page
  51. SEYEDIN, S.M., CARTILAGE-INDUCING FACTOR-A - APPARENT IDENTITY TO TRANSFORMING GROWTH-FACTOR-BETA, JOURNAL OF BIOLOGICAL CHEMISTRY 261: 5693 (1986). · DOI · Paper page
  52. SEYEDIN, S.M., PURIFICATION AND CHARACTERIZATION OF 2 CARTILAGE-INDUCING FACTORS FROM BOVINE DEMINERALIZED BONE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 2267 (1985).
  53. SHAPIRO, J.R., IMPERFECT OSTEOGENESIS AND OSTEOPOROSIS, NEW ENGLAND JOURNAL OF MEDICINE 310: 1738 (1984). · doi:10.1056/nejm198406283102610
  54. SHIPLEY, G.D., REVERSIBLE INHIBITION OF NORMAL HUMAN PROKERATINOCYTE PROLIFERATION BY TYPE-BETA TRANSFORMING GROWTH FACTOR-GROWTH INHIBITOR IN SERUM-FREE MEDIUM, CANCER RESEARCH 46: 2068 (1986).
  55. 10.1126/science.6572416 · DOI · Paper page
  56. TASHJIAN, A.H., ALPHA AND BETA HUMAN TRANSFORMING GROWTH-FACTORS STIMULATE PROSTAGLANDIN PRODUCTION AND BONE-RESORPTION IN CULTURED MOUSE CALVARIA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 82: 4535 (1985).
  57. TUCKER, R.F., COMPARISON OF INTRACELLULAR AND EXTRACELLULAR TRANSFORMING GROWTH-FACTORS FROM NONTRANSFORMED AND CHEMICALLY TRANSFORMED MOUSE EMBRYO CELLS, CANCER RESEARCH 43: 1581 (1983).
  58. Tucker, R. F., Proceedings of the National Academy of Sciences of the United States of America 81: 6757 (1984).
  59. 10.1126/science.6093254 · DOI · Paper page
  60. Wahl, S. M., Cellular Functions in Immunity and Inflammation: 453 (1981).
  61. YING, S.Y., INHIBIN AND BETA-TYPE TRANSFORMING GROWTH-FACTOR (TGF-BETA) HAVE OPPOSITE MODULATING EFFECTS ON THE FOLLICLE-STIMULATING-HORMONE (FSH)-INDUCED AROMATASE-ACTIVITY OF CULTURED RAT GRANULOSA-CELLS, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 136: 969 (1986). · DOI

Cited by

See all 1,182

Metadata

Authors
Sporn, M. B., Roberts, A. B., Wakefield, L. M., & Assoian, R. K.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1986-08
Volume
233
Issue
4763
Pages
532-534
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.3487831
OpenAlex
W2007768242
Cited by
1,182
References
1
FWCI
45.73
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Transforming Growth Factor-β: Biological Function and Chemical Structure. https://app.cochat.ai/papers/10.1126/science.3487831
The paper
Sporn, M. B., Roberts, A. B., Wakefield, L. M., & Assoian, R. K. (1986). Transforming Growth Factor-β: Biological Function and Chemical Structure. Science. https://doi.org/10.1126/science.3487831

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.