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Extended Culture of Mouse Embryo Cells Without Senescence: Inhibition by Serum
Abstract
Mouse embryo cells cultured in vitro in serum-supplemented media undergo growth crisis, resulting in the loss of genomically normal cells prior to the appearance of established, aneuploid cell lines. Mouse embryo cells established and maintained for multiple passages in the absence of serum did not exhibit growth crisis or gross chromosomal aberration. Cells cultured under these conditions were dependent on epidermal growth factor for survival. Proliferation was reversibly inhibited by serum or platelet-free plasma, suggesting that mouse embryo cultures maintained by conventional procedures are under the influence of inhibitory factors.
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Cited by
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Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038
Sherr, C. J., & DePinho, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00046-5 · Cited by 745
Hallmarks of senescence in carcinogenesis and cancer therapy
Shay, J. W., & Roninson, I. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207518 · Cited by 502
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
Ramirez, R. D., Morales, C. P., Herbert, B.-S., Rohde, J. M., Passons, C., Shay, J. W., & Wright, W. E. (2001) · Genes & Development · doi:10.1101/gad.859201 · Cited by 444
Development and applications of a molecular genetic linkage map of the mouse genome
Copeland, N. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90085-5 · Cited by 440
Metadata
- Authors
- Loo, D. T., Fuquay, J. I., Rawson, C. L., & Barnes, D. W.
- Venue
- Science
- Published
- 1987-04-10
- Volume
- 236
- Issue
- 4798
- Pages
- 200-202
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039442999
- Cited by
- 219
- References
- 0
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Extended Culture of Mouse Embryo Cells Without Senescence: Inhibition by Serum. https://app.cochat.ai/papers/10.1126/science.3494308
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- Loo, D. T., Fuquay, J. I., Rawson, C. L., & Barnes, D. W. (1987). Extended Culture of Mouse Embryo Cells Without Senescence: Inhibition by Serum. Science. https://doi.org/10.1126/science.3494308
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
