The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Differentiation-Linked Leukemogenesis in Lymphocytes
Abstract
Most human lymphoid malignancies preserve a pattern of gene expression reflecting their proliferative activity and the developmental level of clonal expansion and maturation arrest. Characteristics of leukemia and other cancer cells frequently considered to reflect aberrant differentiation may more often reflect clonal selection of cell types that are normally infrequent and transitory. The differentiation status of progenitor or mature lymphoid cells influences which genetic elements are at risk of being exploited, via mutation, recombination, or deletion, for clonal advantage. These alterations may frequently arise spontaneously as a consequence of the unique developmental and functional programs of lymphoid cells and have as a major phenotypic consequence the stabilization of transitory cellular phenotypes.
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Citations
Cites
Nowell, P. C. (1976) · Science · doi:10.1126/science.959840 · Cited by 6,471
Sutherland, R., Delia, D., Schneider, C., Newman, R., Kemshead, J., & Greaves, M. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.7.4515 · Cited by 685
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Cited by
Mechanisms of B-cell lymphoma pathogenesis
Küppers, R. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1589 · Cited by 965
Origins of chromosome translocations in childhood leukaemia
Greaves, M. F., & Wiemels, J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1164 · Cited by 699
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Metadata
- Authors
- Greaves, M. F.
- Venue
- Science
- Published
- 1986-11-07
- Volume
- 234
- Issue
- 4777
- Pages
- 697-704
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974260935
- Cited by
- 338
- References
- 2
- FWCI
- 38.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Greaves, M. F. (1986). Differentiation-Linked Leukemogenesis in Lymphocytes. Science. https://doi.org/10.1126/science.3535067
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
